Elsevier

Pediatric Neurology

Volume 9, Issue 3, May–June 1993, Pages 227-229
Pediatric Neurology

Case report
PCR diagnosis of primary herpesvirus type I in poliomyelitis-like paralysis and respiratory tract disease

https://doi.org/10.1016/0887-8994(93)90091-PGet rights and content

Abstract

Successful and rapid recovery of HSV-1 DNA from the cerebrospinal fluid after amplification by polymerase chain reaction was obtained in a 7-year-old boy with subtotal and permanent upper extremity paralysis with rapid onset and magnetic resonance imaging evidence of cervical cord involvement. Early administration of intravenous acyclovir probably limited neuronal loss. The clinical course and outcome of this disorder best conformed with what has been described as poliomyelitis-like paralysis associated with respiratory tract infection (Hopkins syndrome).

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    Citation Excerpt :

    When a viral infection triggers an asthmatic attack, the virus can also invade the anterior horn cells, similar to the findings in poliomyelitis virus. Various microorganisms, including adenovirus type 3, echovirus type 18, Coxsackie virus type B5, Mycoplasma[5], and herpes simplex [6], were described in association with the illness. The clinical changes resemble those of acute poliomyelitis with acute lower motor neuron disorder, without sensory involvement, the presence of inflammatory changes in cerebrospinal fluid, and the residual wasting of muscles.

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