Original articleTwo-phase [11C]l-methionine PET in childhood brain tumors☆
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2018, World NeurosurgeryCitation Excerpt :Giammarile et al.82 observed a tumor/normal tissue ratio of around 1 (range, 0.9–1.8) and higher accumulation (range, 1.4–5.9) on FDG and [11C]methionine PET. Contrary to the FDG and [11C]methionine PET in liponeurocytomas and central neurocytomas, ependymomas and medulloblastomas show higher FDG and [11C]methionine uptake in PET examinations,83-86 whereas dysembryoplastic neuroepithelial tumors show lower and normal to slightly higher uptake compared with normal cortex on those studies.87 Horstmann et al.88 observed the genetic profile of the cerebellar liponeurocytoma to differentiate the cerebellar liponeurocytoma genetically from the cerebellar medulloblastoma and the central neurocytoma after collecting 20 tumor samples from 20 patients worldwide.
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2012, Handbook of Clinical NeurologyMolecular Imaging (PET) of Brain Tumors
2009, Neuroimaging Clinics of North AmericaPET and MR Imaging of Brain Tumors
2008, PET ClinicsCitation Excerpt :MET-PET has been studied to determine its value in a variety of roles in the evaluation of neoplasms, including detection, delineation of tumor, grading, prognosis, and effectiveness of therapy. MET accumulates in gliomas, as demonstrated by multiple prior studies, and MET-PET has repeatedly demonstrated that it is a very sensitive tool for detection of brain neoplasms.39,82–86 The sensitivities for malignant neoplasms have ranged from 61% to 97%, with higher rates for higher grade neoplasms.85
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Supported in part by NIH Grants CA 32846 and NS 15080 and by the Children's Cancer foundation.