Original contributionRelationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction
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Diffusion weighted imaging in acute ischemic stroke: A review of its interpretation pitfalls and advanced diffusion imaging application
2021, Journal of the Neurological SciencesCitation Excerpt :One study evaluated CBF levels and changes in adenosine triphosphate, lactate, and pH corresponding to DWI lesions in a rat MCA occlusion model. [47] It showed that the area of DWI lesion matched with the area of tissue acidosis with low pH, but it was larger than the area of reduced adenosine triphosphate (core), implying DWI lesion included the ischemic core and the penumbra. [47] This study also showed that tissue acidosis, adenosine triphosphate depletion and DWI changes were noted at higher CBF thresholds at 2 h after onset of ischemia compared to that at 30 min after onset.
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Copyright © 1994 Published by Elsevier Inc.