Oncogenous osteomalacia: a case study

https://doi.org/10.1016/0169-6009(89)90050-0Get rights and content

Abstract

A case of oncogenous osteomalacia due to a fibrosarcoma of the maxilla is reported, with a 19 year course before treatment. Metabolic studies of calcium and phosphorus were performed 3 and 19 years after the first symptomology. There was a negative balance for both phosphorus and calcium with low serum levels of 1,25-dihydroxyvitamin D which were corrected by resection of the tumor. Portions of the tumor were cultured and the supernatant did not affect phosphorus transport by a proximal tubule kidney cell line. Other portions were injected into athymic nude mice where they resulted in hypophosphatemia and phosphaturia, thus confirming the endocrine nature of the oncogenous osteomalacia factor.

Reference (18)

There are more references available in the full text version of this article.

Cited by (24)

  • Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature

    2009, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
    Citation Excerpt :

    Craniofacial localization has been described in only 5% of cases, with the paranasal sinuses being the most favored sites in this region.1 Involvement of the mandible and mandibular soft tissues is exceptionally rare with only 4 clear cases reported in the English-language literature to date (Table III).1,7,9,19-26 As expected, most PMTMCTs are discovered in middle-aged adults, although cases have been documented in patients ranging from 3 to 73 years of age.1

  • Tumor-Induced Osteomalacia

    2008, Principles of Bone Biology: Volume 1-2, Third Edition
  • Oncogenic osteomalacia: induced by tumor, cured by surgery

    2007, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
    Citation Excerpt :

    Lower limb, head and neck area, and upper limb are known as the frequent occurring sites in this order. As far as we are aware, the present case is the tenth case reported in the oral and maxillofacial region (Tables I and II).3,5,7-22 In osteomalacia, a decrease in the inorganic content of bone causes lower bone density, and in severe cases, typical patterns of pseudofracture can be seen on plain film.

  • Tumor-induced osteomalacia

    1995, Seminars in Arthritis and Rheumatism
View all citing articles on Scopus
View full text