ArticlesRandomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies
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Neonatal Pain and Stress
2023, Avery's Diseases of the NewbornNeonatal Pain and Stress: Assessment and Management
2018, Avery's Diseases of the Newborn: Tenth EditionNeonatal Pain and Stress: Assessment and Management
2017, Avery's Diseases of the Newborn, Tenth EditionSedation and analgesia to facilitate mechanical ventilation
2013, Clinics in PerinatologyCitation Excerpt :Among the first to suggest clinical benefit, the NOPAIN trial reported decreased rates of periventricular leukomalacia, severe IVH, and death when morphine was prophylactically infused into mechanically ventilated premature neonates.65 Other small, randomized controlled trials reported improved ventilator synchrony and serum stress markers in response to morphine.28,29,111 In contrast, 2 large, placebo-controlled trials could not demonstrate the benefit of morphine for intubated neonates found in smaller trials.
Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment
2013, International Journal of Developmental NeuroscienceCitation Excerpt :For critically ill neonates, pain and stress must be carefully managed. Although, several clinical trials have found morphine effective for reducing stress in ventilated preterm infants (Anand, 2001; Orsini et al., 1996; Quinn et al., 1993), more recent trials have found no benefit of morphine infusion on stress or neurological outcomes in preterm infants (Anand et al., 2004; Simons et al., 2003) and a subsequent Cochrane systematic review concluded that there was insufficient evidence to support routine use of opioids in ventilated neonates (Bellu et al., 2005). And the risks of neonatal morphine may outweigh the benefits.