ORIGINAL ARTICLESEffects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfism
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Growth hormone, insulin-like growth factors, and IGF binding proteins
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2016, Growth Hormone and IGF ResearchNormal and Aberrant Growth in Children
2015, Williams Textbook of EndocrinologyDisorders of growth hormone/insulin-like growth factor secretion and action
2014, Pediatric Endocrinology: Fourth EditionBiphasic response of subscapular skinfold thickness to hGH or IGF-1 administration to patients with congenital IGHD, congenital MPHD and Laron syndrome
2014, Obesity Research and Clinical PracticeCitation Excerpt :Laron syndrome patients (OMIM# 262500) lacking GH activity and IGF-1 deficient, become progressively obese [15,16]. Short term IGF-1 replacement therapy was shown to decrease the subcutaneous fat both in children and adult patients [17,18]. In the present report we show that long term administration of hGH or IGF-1 to three distinct diagnostic entities of congenital hGH/IGF-1 deficient children results in a biphasic effect on the subcutaneous adipose tissue depending on the length of the hormone administration.
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