LETTERS to the EDITORChromosomal aberrations defining uveal melanoma of poor prognosis
References (8)
- et al.
Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation
Am J Ophthalmol
(1985) - et al.
Relative survival rates after alternative therapies for uveal melanoma
Ophthalmology
(1990) - et al.
Monosomy 3 and isochromosome 8q in a uveal melanoma
Cancer Genet Cytogenet
(1990) - et al.
Tnsomy 7p in an ocular melanoma
Surv Ophthalmol
(1988)
Cited by (74)
Choroidal and ciliary body melanoma, the Zimmerman hypothesis
2023, Ophthalmic Pathology: The Evolution of Modern ConceptsTranslation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology
2021, Progress in Retinal and Eye ResearchCitation Excerpt :Several other clinical and histological features are used to complement the conventional AJCC UM staging and patient prognosis (Kaliki et al., 2015; Mäkitie et al., 1999) (Fig. 1). However, a major twist came from cytogenetic studies identifying that the recurrent loss of chromosome 3 and gain of chromosome 8q in tumours (Horsman et al., 1990; Prescher et al., 1992; Sisley et al., 1990) were associated with poor prognosis tumours (Damato et al, 2007, 2009; Jager et al., 2020; Pandiani et al., 2017; Smit et al., 2020; Trolet et al., 2009). Adding chromosome status together with the AJCC resulted in an even better system (Bagger et al., 2015).
Variability of Bad Prognosis in Uveal Melanoma
2019, Ophthalmology RetinaUpdate on Tumor-Node-Metastasis Staging for Uveal Melanoma
2016, Advances in Ophthalmology and OptometryCitation Excerpt :Among these, loss of 1 copy of chromosome 3 (known as monosomy 3) has emerged as a powerful predictor of metastatic risk. Monosomy 3, which can be detected using a variety of techniques, is found in the majority of metastasizing uveal melanoma [17–21]. Gene expression profiling also has been developed for uveal melanoma risk stratification.