Malakoplakia of kidney simulating renal neoplasm

doi:10.1016/0090-4295(77)90143-1

Urology

Volume 10, Issue 5, November 1977, Pages 472-477

https://doi.org/10.1016/0090-4295(77)90143-1 Get rights and content

Abstract

In a nine-year-old girl with renal hypertension and a urinary infection, angiographic studies of the left kidney suggested an intrarenal pheochromocytoma. After nephrectomy, the kidney was found to contain only a cystic lesion characterized by multiple small, friable excrescences. Under the light microscope these appeared to be formed by granulovacuolated macrophages. Electron microscopy showed intracytoplasmic inclusion identified as Michaelis-Gutmann bodies in various stages of formation. Images suggestive of degraded bacteria were also observed within phagolysosomes.

References (25)

A. Gonzalez-Angulo et al.
Malakoplakia of the colon
Gastroenterology
(1965)
T.Y. Lou et al.
Malakoplakia: pathogenesis and ultrastructural morphogenesis
Human Pathol.
(1974)
R.L. Goldman
A case of malakoplakia with involvement of the prostate gland
J. Urol.
(1965)
T. An et al.
Observations on the formation of Michaelis-Gutmann bodies
Human Pathol.
(1974)
I. Purpon et al.
Malakoplakia of the kidney
J. Urol.
(1960)
H.M. Price et al.
Malakoplakia of the skin: an electron microscopic study
Human Pathol.
(1973)
L. Michaelis et al.
Ueber Einschlusse in Blasentumoren
Z. Klin. Med.
(1902)
W.M.S. Blackshear
Malakoplakia of the appendix: a case report
Am. J. Clin. Pathol.
(1970)
T.V. DiSilvia et al.
Malakoplakia of the colon
Arch. Pathol.
(1971)
L.R. Finlay-Jones et al.
Malakoplakia of the colon
Am. J. Clin. Pathol.
(1968)

A.M. Rywlin et al.

Malakoplakia of the colon

Am. J. Dig. Dis.

(1969)

J.Y. Terner et al.

Malakoplakia of colon and retroperitoneum

Am. J. Clin. Pathol.

(1965)

Cited by (24)

Renal Malacoplakia Reappraised
1993, American Journal of Kidney Diseases
Renal malacoplakia is an unusual form of chronic tubulointerstitial nephritis with a predilection for patients with recurrent urinary tract infections and an immunocompromised state. Its characteristic feature is the parenchymal infiltration by macrophages with ample cytoplasm containing abundant periodic acid-Schiff-positive granules, known as von Hansemann cells, and the presence of diagnostic extracytoplasmic or intracytoplasmic calcospherites, known as Michaelis-Gutmann bodies. Renal malacoplakia is more common in women (female to male ratio 3:1), in whom the lesions develop in a younger age group (third to fifth decade) than in men (over 50 years). Enlarged kidneys in the presence of persistent urinary infection should lead to the consideration of this entity. The diagnosis can only be established by pathologic examination of renal tissue. Renal biopsy early in the course of the disease is essential since in an increasing number of cases medical therapy has resulted in resolution of the disease process and preservation of renal function.
Renal Malacoplakia With Papillary Necrosis and Renal Failure
1992, American Journal of Kidney Diseases
Renal parenchymal malacoplakia is a rare cause of renal failure. Patients presenting with renal failure carry a poor prognosis, the majority either dying or requiring chronic dialysis. In this report, we describe an alcoholic man who presented with renal failure due to bilateral renal parenchymal malacoplakia and papillary necrosis. The patient, who initially required dialysis, partially recovered renal function following prolonged antibiotic treatment with a fluoroquinolone antibiotic.
Malacoplakia: A study of the literature and current concepts of pathogenesis, diagnosis, and treatment
1981, Journal of Urology
Mass lesions in the transplanted kidney: Answers
2015, Pediatric Nephrology
Nonneoplastic diseases of the kidney
2013, Urological Pathology
Kidney and renal pelvis: Inflammation
2013, Abdominal Imaging

View all citing articles on Scopus

View full text

Malakoplakia of kidney simulating renal neoplasm

Abstract

Gastroenterology

Human Pathol.

J. Urol.

Human Pathol.

J. Urol.

Human Pathol.

Ueber Einschlusse in Blasentumoren

Z. Klin. Med.

Malakoplakia of the appendix: a case report

Am. J. Clin. Pathol.

Malakoplakia of the colon

Arch. Pathol.

Malakoplakia of the colon

Am. J. Clin. Pathol.

Malakoplakia of the colon

Am. J. Dig. Dis.

Malakoplakia of colon and retroperitoneum

Am. J. Clin. Pathol.