Alimentary tractIs the afferent pathway from the rectum impaired in children with chronic constipation and encopresis?☆,☆☆
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Cited by (47)
Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer
2018, Radiotherapy and OncologyCitation Excerpt :We found prolonged latencies of the CEPs elicited by rectal distensions suggesting that AC patients have abnormal afferent neural pathways from the rectum to the brain. Prolonged CEP latencies after rectal stimuli have previously been described in patients with fecal and urinary incontinence, constipated children, and constipated adults with rectal hyposensitivity [32,42–44]. This likely represents aberrant (mechano-) receptor function or abnormal propagation properties of the afferent pathways, likely due to damage of the peripheral nerves.
Anorectal manometry with and without ketamine for evaluation of defecation disorders in children
2015, Journal of Pediatric SurgeryCitation Excerpt :In constipated children, there have been reports of abnormal manometry profile of up to two folds increase in thresholds of rectal sensation, critical volume and RAIR as it was observed in this series [9,11,25]. In contrast, the first rectal sensory threshold and the critical volume in healthy children have been reported to be lower being 17 ± 7.1 and 101 ± 39, respectively [26,27]. It has been suggested that a defect is present in the afferent neural pathway of the rectum in children who have chronic functional constipation.
Anorectal functional abnormalities in Egyptian children with chronic functional constipation
2013, Arab Journal of GastroenterologyConstipation Is Associated With Spina Bifida Occulta in Children
2008, Clinical Gastroenterology and HepatologyBotulinum toxin, a new treatment modality for chronic idiopathic constipation in children: long-term follow-up of a double-blind randomized trial
2007, Journal of Pediatric SurgeryCitation Excerpt :Other stimulants, such as Movicol and sodium picosulfate, were given if a child did not pass bowel motion for 3 days or as additional bowel stimulants over weekends. At least 2 of the following 4 criteria should have been fulfilled for the definition of constipation and fecal soiling: stool frequency of less than 3 times per week; soiling frequency of 2 or more times per week; periodic passage of large amounts of stool at least once every 7 to 30 days; and presence of a palpable abdominal or rectal mass [21,22]. Patients were excluded from the study if they had an underlying anorectal anomaly or endocrine abnormality, neuropathic bowel, learning difficulties, and evidence of anal sphincter damage on endosonography or a low anal sphincter pressure of less than 30 mm Hg on manometry.
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Supported by the Children's Miracle Network Telethon and grant M01-RR-00059 from the General Clinical Research Center Program, Division of Research Resources, National Institutes of Health.
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Presented in part at the American Gastroenterological Association meeting in Boston, Massachusetts, May 19, 1993, and published in abstract form (Gastroenterology 1993;104:A544).