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Salivary Cotinine, Doctor-diagnosed Asthma and Respiratory Symptoms in Primary Schoolchildren

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Abstract

Due to impaired airway function, children are at risk for adverse respiratory symptoms if exposed to environmental tobacco smoke (ETS). A community-based, cross-sectional study of 425 children (5–11 years) attending 15 primary schools in a low socio-economic area of Merseyside/UK was undertaken to investigate the association of adverse respiratory symptoms and ETS exposure using a parent-completed questionnaire and children’s salivary cotinine measurements. Overall, 28.9% of children had doctor-diagnosed asthma (DDA) and 11.3% a history of hospital admission for respiratory illnesses. The symptom triad of cough, wheeze and breathlessness (C+W+B+) occurred in 12.6% of children. The geometric mean cotinine level was 0.37 ng/ml (95% CI, 0.33–0.42 ng/ml) and it was estimated that 45.6% of children were ETS exposed. A history of asthma in the family was reported for 9.2% of fathers and 7.2% of mothers. Salivary cotinine level was significantly increased in children with DDA compared to those without (P = 0.002). Cotinine-validated levels [adjusted odds ratio (AOR), 1.8; 95% CI, 1.4–2.5), low socio-economic (disadvantaged) status (AOR, 1.4; 1.1–2.9), child’s male gender (AOR, 1.6; 1.1–2.5) and maternal smoking (AOR, 2.2; 1.4–3.1) were significantly associated with DDA. The cotinine-validated level (AOR, 1.4; 1.1–2.9) as well as maternal smoking (AOR, 1.8; 1.1–2.5), were also independently associated with C+W+B+. The use of salivary cotinine as an indicator of ETS exposure could be used to inform parents of exposure risk to their asthmatic children and may help re-enforce deterrent efforts to reduce childhood parental smoking exposure.

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Acknowledgments

The assistance of Mr Gregory Harper, Mrs Farideh Yavandi and Mr Mostafa Delpisheh as well as the cooperation of parents and head teachers are gratefully acknowledged. This study was funded by a grant from the Sefton Health Authority.

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Authors and Affiliations

  1. Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK

    Ali Delpisheh, Shaheen Rizwan & Bernard J. Brabin

  2. Department of Community Medicine, Ilam University of Medical Sciences, Ilam, Iran

    Ali Delpisheh

  3. Department of Epidemiology & Public Health, University College London, London, UK

    Yvonne Kelly

  4. Department of Community Child Health, Royal Liverpool Children’s Hospital, Alder hey, NHS Trust, Liverpool, UK

    Bernard J. Brabin

  5. Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

    Bernard J. Brabin

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  1. Ali Delpisheh
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  4. Bernard J. Brabin
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Correspondence to Ali Delpisheh.

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Delpisheh, A., Kelly, Y., Rizwan, S. et al. Salivary Cotinine, Doctor-diagnosed Asthma and Respiratory Symptoms in Primary Schoolchildren. Matern Child Health J 12, 188–193 (2008). https://doi.org/10.1007/s10995-007-0229-9

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  • DOI: https://doi.org/10.1007/s10995-007-0229-9

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