Abstract
Aims
The aim of the study was (a) to compare annual glycemic control in pediatric patients with type 1 diabetes mellitus (T1DM) who used a healthcare-funded continuous glucose monitoring system (RT-CGMS) to that of those who performed self-monitoring blood glucose (SMBG) only, in a real-life setting, and (b) to define parameters associated with compliance and glycemic control.
Methods
A total of 149 youth with T1DM (52.3 % females), mean age 11.8 ± 3.6 years, and 83 in the CGMS group were followed prospectively for 12 months. Glycemic control parameters and compliance to RT-CGMS were assessed periodically.
Results
Glycemic parameters did not differ significantly between the groups during follow-up periods. The time spent with RT-CGMS decreased and only 38 % used it for more than 75 % of the time during the 12 months (consistent users). Mean HbA1c decreased by 0.27 % in consistent users and increased by 0.21 % among intermittent users (used RT-CGMS less than 75 % of time), p = 0.013. Consistent users were younger 10. 6 ± 4.2 vs. 12.5 ± 3.6, p = 0.07, and had higher frequency of SMBG at baseline, 10.6 ± 4.9 vs. 6.3 ± 2.8, p = 0.011.
Conclusions
The adoption of RT-CGMS was low, even in a healthcare system that funds its use. Caregivers should consider patient characteristics when recommending RT-CGMS use.
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Acknowledgments
We thank Ms. Cindy Cohen for her editorial assistance.
Conflict of interest
The authors Rachmiel Marianna, Landau Zohar, Mazor Aronovitch Kineret, Loewenthal Neta, Ben-Ami Michal, Levy-Shraga Yael, Modan-moses Dalit, Haim Alon, Abiri Shirli, Pinhas-Hamiel Orit, Boaz Mona declare that they have no conflict of interest.
Human and Animal rights
All procedures followed were in accordance with the ethical standards of the responsible committees on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.
Informed consent
Informed consent was obtained from participants for being included in the study according to Ethics Committees requirements.
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Managed by Massimo Porta.
M. Rachmiel and Z. Landau have equally contributed to this work.
Trial registry number: NCT01525784.
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Rachmiel, M., Landau, Z., Boaz, M. et al. The use of continuous glucose monitoring systems in a pediatric population with type 1 diabetes mellitus in real-life settings: the AWeSoMe Study Group experience. Acta Diabetol 52, 323–329 (2015). https://doi.org/10.1007/s00592-014-0643-6
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DOI: https://doi.org/10.1007/s00592-014-0643-6