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Patients’ evaluation of nocturnal hypoglycaemia with GlucoDay continuous glucose monitoring in paediatric patients

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Abstract

A study was conducted to evaluate the accuracy of GlucoDay (A. Menarini Diagnostics) during 48 h of continuous glucose monitoring (CGMS) in type 1 diabetic adolescents and use this novel approach to assess otherwise ignored nocturnal hypoglycaemias, in relationship to intermediate-acting insulin administration timing. Twenty type 1 diabetic adolescents with poor metabolic control were selected from our out-patient department. Equal doses of intermediate insulin were administered at 19:00 and at 22:00 of the first and second night of the study, respectively. Correlation coefficient between GlucoDay and standard glucometer was 0.94; 98.3% of data fall in the A + B area of Error Grid Analysis and 1.7% in the D area. The mean error was 13.9% overall and 16.4% with blood glucose values (BGV) <75 mg/dl. The accuracy, ±15 mg/dl, was 82% for BGV <75 mg/dl and 74% for BGV >75 mg/dl. The CGMS discovered nocturnal hypoglycaemia (NH) in 12/18 patients, but no severe hypoglycaemia. During the first night, 8 asymptomatic NH episodes were found with BGV <60 mg/dl and 12 with BGV <80. During the second night, 4 asymptomatic NH episodes with BGV <60 mg/dl and 5 with BGV <80 were found. Furthermore, during the second night, the mean duration of BGV <126 mg/dl was lower than in the first night. GlucoDay is a reliable device for CGMS in paediatric patients and able to determine asymptomatic NH. Bedtime insulin injections provided safer glycaemic profiles and a lower percentage of hypoglycaemic events, representing a safer insulin administration scheme.

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Acknowledgments

This study was funded by a research grant from Menarini I.F.R., Florence, Italy. We thank Alessandro Poscia, Silvia Beghin, and Alberto Maran for their expert assistance.

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Authors and Affiliations

  1. Paediatric Department, Scientific Institute H San Raffaele, Vita-Salute University, Milan, Italy

    Franco Meschi, Riccardo Bonfanti, Andrea Rigamonti, Frontino Giulio, Roseila Battaglino, Matteo Viscardi & Giuseppe Chiumello

  2. Menarini I.F.R., Florence, Italy

    Alessandro Poscia

  3. Centro di Endocrinologia dell’Infanzia e dell’Adolescenza, Scientific Institute H San Raffaele, Università Vita-Salute, Via Olgettina 60, 20132, Milan, Italy

    Roseila Battaglino

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  1. Franco Meschi
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  2. Riccardo Bonfanti
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  3. Andrea Rigamonti
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  4. Frontino Giulio
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  5. Roseila Battaglino
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  6. Matteo Viscardi
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  7. Alessandro Poscia
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  8. Giuseppe Chiumello
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Correspondence to Roseila Battaglino.

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Meschi, F., Bonfanti, R., Rigamonti, A. et al. Patients’ evaluation of nocturnal hypoglycaemia with GlucoDay continuous glucose monitoring in paediatric patients. Acta Diabetol 47, 295–300 (2010). https://doi.org/10.1007/s00592-010-0181-9

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  • DOI: https://doi.org/10.1007/s00592-010-0181-9

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