Summary
The larger extravascular spaces play an important role in the distribution of Ethambutol and resulting blood levels in children. For this reason serum levels in children of different age groups 2 – < 6 years, 6 – < 10 years and 10–14 years were determined after administration of 15 mg/kg and 25 mg/kg body weight in a single oral dose. Blood samples were drawn before, 1, 2, 4 and 7 hours after the ingestion of Ethambutol. Serum levels were determined by a modified tube vertical diffusion test using our own mycobacterial strain with the same sensitivity as strain ATCC 607. After 15 mg/kg the 2 mcg/ml serum concentration which is necessary for therapeutic efficacy (according to Pyle and Schmidt) was not achieved.
The administration of 25 mg/kg produced serum concentrations of 2 mcg/ml and more only in the 10–14 years age group. According to v. Harnack and C. Simon, chemotherapeutic agents must be administered according to square meters of body surface to give equal serum concentrations in all age groups. Taking this into account and according to our results the dosage of 25 mg/kg body weight is too low for children in the age group 2 to < 10 years.
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Hussels, H., Otto, H.S. Ethambutol-Serumkonzentrationen im Kindesalter. Pneumologie 145, 392–396 (1971). https://doi.org/10.1007/BF02095059
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DOI: https://doi.org/10.1007/BF02095059