Skip to main content
SpringerLink
Log in

Stress ulcer prophylaxis and gastric alkalinization — death of a myth?

  • Editorials
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Skillman JJ, Gould SA, Chung RSK, Silen W (1970) The gastric mucosal barrier: clinical and experimental studies in critically ill and normal man and in the rabbit. Ann Surg 172:564–584

    Google Scholar 

  2. Hase T, Anderson PR, Mehlmann P (1975) Significance of gastric secretory changes in pathogenesis of stress ulcers. Dig Dis 20:443–449

    Google Scholar 

  3. McClelland RN, Shires GT, Prager M (1971) Gastric secretory and splanchnic blood flow studies in man after severe trauma and hemorrhagic schock. Am J Surg 121:134–142

    Google Scholar 

  4. Fiddian-Green RG, McGough E, Pittenger G, Rothman E (1983) Predictive value of intramural pH and other risk factors for massive bleeding from stress ulceration. Gastroenterology 85:613

    Google Scholar 

  5. Fusamoto H, Hagiwara H, Meren H, Ksahara A, Hayashi N, Kawano S, Sugimoto T, Kamada T (1991) A clinical study of acute gastrointestinal hemorrhage associated with various shock states. Am J Gastroenterol 86:429–433

    Google Scholar 

  6. Lucas CE (1981) Stress ulceration: the clinical problem. World I Surg 5:139–151

    Google Scholar 

  7. Stannard VA, Hutchinson A, Morris DL, Byrne A (1988) Gastric exocrine “failure” in critically ill patients: incidence and associated features. Br Med J 296:155–156

    Google Scholar 

  8. Urakawa T, Nagahata Y, Azumi Y, Sano I, Takeda K, Hashimoto Y, Ichihara T, Morimoto H, Saitoh Y (1989) The mechanism of acute gastric ulcer after induced hemorrhagic shock. Scand J Gastroenterol 24:193–201

    Google Scholar 

  9. Sato N, Kamada T, Shichiri M, Kawano S, Abe H, Hagihara B (1979) Measurement of hemoperfusion and oxygen sufficiency in gastric mucosa in vivo. Gastroenterology 76:814–819

    Google Scholar 

  10. Kamada T, Sato N, Kawano S, Fusamoto H, Abe H (1982) Gastric mucosal hemodynamics after thermal or head injury. Gastroenterology 83:535–540

    Google Scholar 

  11. Bailey RW, Bulkley GB, Hamilton SR, Morris JB, Haglund UH, Meilahn JE (1987) The fundamental hemodynamic mechanism underlying gastric stress ulceration in cardiogenic shock. Ann Surg 205:597–612

    Google Scholar 

  12. Ephgrave KS, Horton JW (1989) Gastric mucosal perfusion and injury: variation in the relationship over time. J Trauma 29:380–383

    Google Scholar 

  13. Menguy R, Desbaillets L, Masters YF (1974) Mechanism of stress ulcer: influence of hypovolemic shock on energy metabolism in the gastric mucosa. Gastroenterology 66:46–55

    Google Scholar 

  14. Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM (1982) Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 82:9–15

    Google Scholar 

  15. McCord JM, Fridovich I (1968) The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem 243:5753

    Google Scholar 

  16. Fridovich I (1978) The biology of oxygen radicals. Science 201:875

    Google Scholar 

  17. Del Maestro RF, Thaw HH, Björk J, Flankers M, Arfors KE (1980) Free radicals as mediators of tissue injury. Acta Physiol Scand [Suppl] 492:43–57

    Google Scholar 

  18. Moorhouse PC, Grootveld M, Halliwell B, Quinlan JG, Gutteridge JMC (1987) Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS 213:23–28

    Google Scholar 

  19. Itoh M, Guth PH (1985) Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions of the rat. Gastroenterology 88:1162–1167

    Google Scholar 

  20. Von Ritter C, Hinder RA, Oosthuizen MMJ, Svensson LG, Hunter SJS, Lambrecht H (1988) Gastric mucosal lesions induced by hemorrhagic shock in baboons. Dig Dis Sci 33:857–864

    Google Scholar 

  21. Svensson LG, Von Ritter C, Oosthuizen MMJ, Fimmel CJ, Rickards E, Hunter SJS, Robinson MF, Hinder RA (1987) Prevention of gastric mucosal lesions following aortic cross-clamping. Br J Surg 74:282–285

    Google Scholar 

  22. Mantor PC, Tuggle DW, Perkins TA, Shock CK, Askew AA, Tunell WP (1989) Stress-induced gastric ulcers. Curr Surg 388–389

  23. Salim AS (1991) Protection against stress-induced acute gastric mucosal injury by free radical scavengers. Intensive Care Med 17:455–460

    Google Scholar 

  24. Sato N, Hu Quan L, Kawano S, Kamada T, Abe H (1984) Effect of H2 receptor and muscarinic receptor antagonists and prostaglandin E1 analog on the gastric hemodynamics and oxygen sufficiency. In: Bruley D, Bicher HI, Reneau D (eds) Oxygen transport to tissue-VI. Plenum Press, New York, pp 763–771

    Google Scholar 

  25. Chen BW, Hiu WM, Lam SK, Cho CH, NG MMT, Luk CT (1989) Effect of sucralfate on gastric mucosal blood flow in rats. Gut 30:1544–1551

    Google Scholar 

  26. DeWall RA, Vasko KA, Stanley EL, Kezdi P (1971) Responses of the ischemic myocardium to allopurinol. Am Heart J 82:362–370

    Google Scholar 

  27. Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J (1978) Free radicals in cerebral ischemia. Stroke 9:445–447

    Google Scholar 

  28. Flick MR, Hoeffel J, Staub NC (1981) Superoxide dismutase prevents increased lung vascular permeability after air emboli in unanaesthetized sheep. Fed Proc 40:405

    Google Scholar 

  29. Vasco KA, DeWall RA, Riley AM (1972) Effect of alloopurinol in renal ischemia. Surgery 71:787–790

    Google Scholar 

  30. Salim AS (1989) Scavenging free radicals to prevent stress-induced gastric mucosal injury. Lancet II:1390–1391

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University of Bochum “Bergmannsheil”, Gilsingstrasse 14, W-4630, Bochum, FRG

    M. Tryba

Authors
  1. M. Tryba
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tryba, M. Stress ulcer prophylaxis and gastric alkalinization — death of a myth?. Intensive Care Med 18, 1–3 (1992). https://doi.org/10.1007/BF01706416

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01706416

Search

Navigation