Abstract
The acute respiratory distress syndrome (ARDS), a process of non-hydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies carries a high morbidity, mortality (10–90%) and financial cost. The reported annual incidence in the United States is 150000 cases, but this figure has been challenged and may be different in Europe. Part of the reason for these uncertainties is the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those whose wish to know the true incidence and outcome on this clinical syndrome are stymied. The European American Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.
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This conference report is being simultaneously co-published by theAmerican Journal of Respiratory and Critical Care Medicine (formerly theAmerican Review of Respiratory Disease) and theJournal of Critical Care. Copyright is shared byIntensive Care Medicine and theAmerican Journal of Respiratory and Critical Care Medicine. Inquiries about reprints should be directed toIntensive Care Medicine.
Meeting held in Miami, Florida, USA, on May 16, 1992 and in Barcelona, Spain, on October 29, 1992
Co-Chairmen: G.R. Bernard, Vanderbilt University, Nashville, TN, USA, A. Artigas, Sabadell, spain.The Consensus Group Committees: 1) Definitions and strategies for quantification of ARDS severity. Chairpersons: A. Morris,LDS Hospital, Salt Lake City, Utah and J. Carlet, St. Joseph's Hospital, Paris, France. Members included A. Artigas, Sabadell, Spain; B. Cochin, Hôpital de Paris, Paris, France; P.N. Lanken, University of Pennsylvania, Philadelphia, PA; K.V. Leeper, University of Tennessee, Memphis, TN; J. Marini, University of Minnesota, Minneapolis, MN; J.F. Murray, University of California, San Francisco, CA; L. Oppenheimer, University of Manitoba, Canada; A. Pesenti, University of Milan, Monza, Italy; L. Reid, Harvard Medical School, Children's Hospital, Boston, MA; J. Rinaldo, Vanderbilt University, Nashville, TN; and J. Villar, University of Toronto, Toronto, Canada.2) Mechanisms of acute lung injury. Chairpersons: K.L. Brigham, Vanderbilt University Medical School, Nashville, TN and M. Lamy, University of Liege, Belgium. Members included B. Sweder van Asbeck, University of Utrecht, The Netherlands; J.F. Dhainaut, Cochin Port Royal University Hospital Paris, France; J. Mancebo, Barcelona, Spain; M. Matthay, University of California, San Francisco, CA; B. Meyrick, Vanderbilt University Medical School, Nashville, TN; D. Payen, Paris, France; C. Perret, A.A. Fowler, Medical College of Virginia, Richmond, VA; and M.-D. Schaller, University of Lausanne, Lausanne, Switzerland.3) Risk factors, prevalence and relevant outcomes of ARDS. Chairpersons: L. D. Hudson, MD, University of Washington, Seattle, WA and J.R. LeGall, Paris, France. Members included: T. Hyers, St. Louis University, St. Louis, MO; W. Knaus, George Washington University, Washington, DC; R. Matthay, Yale University; M. Pinsky, University of Pittsburgh, Pittsburgh, PA.4) Mechanisms of clinical study coordination. Chairpersons: R. Spragg, University of California, San Diego, CA, and K. Falke, Berlin, Germany. Members included G.R. Bernard, Vanderbilt University Medical School, Nashville, TN; R. C. Bone, Rush Medical College, Chicago, IL; C. Bosken, NIH, NHLBI, Division of Lung Diseases, Bethesda MD (the views of Dr. Bosken are her own and do not necessarily represent those of the NIH/NHLBI); W.G. Johanson, New Jersey School of Medicine, Newark, NJ; K. Lewandowski, Berlin, Germany; J. Repine, University of Colorado Health Sciences Center, Webb Waring Institute for Biomedical Research Denver, CO; R. Rodriguez-Roisin, Hospital Clinic Barcelona, Spain; C. Roussos, Evangelismos Hospital, Athens, Greece.Other contributors: M.A. Antonelli, University degli Studi, Rome, Italy; S. Beloucif, Paris; D. Bihari, Guy's Hospital, London, UK; H. Burchardi, University of Göttingen, Germany; F. Lemaire, Paris; P. Montravers, Paris; T.L. Petty, University of Colorado Health Sciences, Center, Denver, Co; J. Robotham, Baltimore, MD; W. Zapol, Massachusetts General Hospital, Boston, MA
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Bernard, G.R., Artigas, A., Brigham, K.L. et al. Report of the American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinical trial coordination. Intensive Care Med 20, 225–232 (1994). https://doi.org/10.1007/BF01704707
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DOI: https://doi.org/10.1007/BF01704707