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Acute changes in glucose uptake after treatment: the effects of carmustine (BCNU) on human glioblastoma multiforme

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Summary

Sequential positron emission tomographic scans with [18F]-2-fluorodeoxyglucose (PET-FDG) were performed on 6 patients with glioblastoma multiforme who were treated with adjuvant BCNU. Scans were acquired before and 24 hours after BCNU. All patients had prior brain irradiation. Ratios between the maximal tumor FDG uptake and the contralateral white matter FDG uptake, the glucose uptake ratio, were determined. Percent changes in the glucose uptake ratio between the baseline scan and the 24 hour post-treatment scan were of prognostic significance. Patients with the largest percent changes in FDG uptake had the shortest survival. In contrast, neither the baseline glucose uptake ratio nor the visual tumor grade accurately predicted length of survival.

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Authors and Affiliations

  1. Neurology Service, VA Lakeside Medical Center, 333 East Huron, Chicago, IL

    Jack M. Rozental

  2. Department of Neurology, Northwestern University Medical School, 233 East Erie, 60611, Chicago, IL, USA

    Jack M. Rozental

  3. Department of Human Oncology, University of Wisconsin Medical School, 600 Highland Avenue, 53792, Madison, WI, USA

    Justin D. Cohen & Minesh P. Mehta

  4. Department of Neurology, University of Wisconsin Medical School, 600 Highland Avenue, 53792, Madison, WI, USA

    Ross L. Levine

  5. Department of Radiology, University of Wisconsin Medical School, 600 Highland Avenue, 53792, Madison, WI, USA

    Ross L. Levine & Robert J. Nickles

  6. Department of Medical Physics, University of Wisconsin Medical School, 600 Highland Avenue, 53792, Madison, WI, USA

    Robert J. Nickles

  7. Department of Neurology Service, Wm S Middleton Memorial VA Medical Center, 2500 Overlook Terrace, 53705, Madison, WI, USA

    Ross L. Levine & Joan M. Hanson

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  1. Jack M. Rozental
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Rozental, J.M., Cohen, J.D., Mehta, M.P. et al. Acute changes in glucose uptake after treatment: the effects of carmustine (BCNU) on human glioblastoma multiforme. J Neuro-Oncol 15, 57–66 (1993). https://doi.org/10.1007/BF01050264

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