Abstract
Pre-pubertal body growth was followed in eight children with the hyperprostaglandin E syndrome (neonatal Bartter syndrome) treated with indomethacin over a period of 5–12 years. When corrected for prematurity, the general growth pattern was normal, with the exception of a child with delayed therapy. From the first observation (usually at birth) to the start of indomethacin, the mean height standard deviation score (SDS) corrected for prematurity changed from −0.2 to −2.8. During the first 2 years of therapy rapid catch-up growth occurred, followed by a slow adaptation of the growth pattern to that of healthy children born at term. At last observation the mean corrected height SDS was −0.5 range −1.9 to +0.9) and the mean target height −0.9 SDS (range −1.8 to +0.1). Weight, body mass index and bone maturation also reached the normal range. No correlation was found between height SDS per year and serum potassium levels or calcium excretion. We conclude that under indomethacin treatment long-term skeletal growth of children with the hyperprostaglandin E syndrome is similar to that of other preterm children.
Similar content being viewed by others
References
Seyberth HW, Rascher W, Schweer H, Kühl PG, Mehls O, Schärer K (1985) Congenital hypokalemia with hypercalciuria in preterm infants: a hyperprostaglandinuric tubular syndrome different from Bartter's syndrome. J Pediatr 107: 694–701
Seyberth HW, Königer SJ, Rascher W, Kühl PG, Schweer H (1987) Role of prostaglandins in hyperprostaglandin E syndrome and in selected renal tubular disorders. Pediatr Nephrol 1: 491–497
Fanconi A, Schachenmann G, Nüssli R, Prader A (1971) Chronic hypokalaemia with growth retardation, normotensive hyperreninhyperaldosteronism (“Bartter's syndrome”), and hypercalciuria. Report of two cases with emphasis on natural history and on catch-up growth during treatment. Helv Paediatr Acta 27 2: 144–163
Bartter FC, Pronove P, Gill JR, MacCardle RC (1962) Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. Am J Med 33: 811–828
Royer P, Delaitre R, Mathieu H, Gabilan JC, Raynoud C, Pasqualini JR (1964) L'hypokaliemie chronique idiopathique avec hyperkaliurie de l'enfant. Rev Fr Etud Clin Biol 9: 61–87
Rodriguez-Soriano J (1994) Tubular disorders of electrolyte regulation. In: Holliday MA, Barratt TM, Avner ED (eds) Pediatric Nephrology, 3rd edn. Williams and Wilkins, Baltimore, pp 624–639
Simopoulos AP, Bartter FC (1972) Growth characteristics and factors influencing growth in Bartter's syndrome. J Pediatr 81: 56–65
Littlewood JM, Lee MR, Meadow SR (1978) Treatment of Bartter's syndrome in early childhood with prostaglandin synthetase inhibitors. Arch Dis Child 53: 43–48
Floret D, David M, Roux A, Hage G-N, Teyssier G (1979) Bartter's syndrome: the long-term effects of indomethacin on growth. Nouv Presse Med 8: 17–21
Lechacz G, Arbus GS, Balfe JW, Wolff ED, Robson L (1979) Effect of ibuprofen on growth in a child with Bartter syndrome. J Pediatr 95: 319–320
Cunningham RJ, Brouhard BH, Berger M, Petrusick T, Travis LB (1979) Long-term use of propranolol, ibuprofen and spironolactone in the management of Bartter's syndrome. Pediatrics 63: 754–756
Simopoulos AP (1979) Growth characteristics in patients with Bartter's syndrome. Nephron 23: 130–135
Proesmans W, Massa G, Vanderschueren-Lodeweyckx M (1988) Growth from birth to adulthood in a patient with the neonatal form of Bartter syndrome. Pediatr Nephrol 2: 205–209
Dillon MJ, Shah V, Mitchell MD (1979) Bartter's syndrome: 10 cases in childhood. Results of long-term indomethacin therapy. Medicine (Baltimore) 48: 429–446
Ohlsson A, Sieck U, Cumming W, Akhtar M, Serenius F (1984) A variant of Bartter's syndrome. Acta Paediatr Scand 73: 868–874
De Rovetto CR, Welch TR, Hug G, Clark KE, Bergstrom W (1989) Hypercalciuria with Bartter syndrome: evidence for an abnormality of vitamin D metabolism. J Pediatr 115: 397–404
Deschenes G, Burguet A, Guyot C, Hubert P, Garabedian M, Dechaux M, Loirat C, Broyer M (1993) Antenatal form of Bartter syndrome. Ann Pediatr (Paris) 40: 95–101
Leonhardt A, Busch C, Timmermanns G, Roth B, Seyberth HW (1992) Calcium homeostasis and hypercalciuria in hyperprostaglandin E syndrome. J Pediatr 120: 546–554
Ellimann AM, Bryan EM, Ellimann AD, Harvey DR (1992) Gestational age correction for height in preterm children to seven years of age. Acta Paediatr 81: 836–839
Albertsson-Wikland K, Wennergren G, Wennergren M, Vilbergsson G, Rosberg S (1993) Longitudinal follow-up of growth in children born small for gestational age. Acta Paediatr 82: 438–443
Prader A, Largo RH, Molinari L, Issler C (1988) Physical growth of Swiss children from birth to 20 years of age. Helv Paediatr Acta [Suppl] 52: 1–125
Brandt I (1978) Growth dynamics of low-birth-weight-infants with emphasis on the perinatal period. In: Falkner F, Tanner JM (eds) Human growth, vol 2. Plenum, New York, pp 577–617
Largo RH, Wälli R, Duc G, Fanconi A, Prader A (1980) Evaluation of perinatal growth. Helv Paediatr Acta 35: 419–436
Georgi M, Kattwinkel I (1994) Normwerte von Körpergröße, Körpergewicht und Körperzusammensetzung bei Kindern und Jugendlichen im Großraum Heidelberg unter Berücksichtigung der bioelektrischen Impedanz-Analyse. Dissertation University of Heidelberg, Germany
Patriquin H, Robitaille P (1986) Renal calcium deposits in children: sonographic demonstration of the Anderson-Carr progression. AJR 146: 1253–1256
Gasser T, Köhler W, Müller HG, Kneip A, Largo R, Molinari L (1984) Velocity and acceleration of height growth using kernel estimation. Ann Hum Biol 11: 397–411
Gasser T (1991) Analysing curves using kernel estimators. Pediatr Nephrol 5: 477–450
Seidel C, Schaefer F, Schärer K (1993) Body growth in urinary tract malformations. Pediatr Nephrol 7: 151–155
Tanner JMI, Goldstein H, Whitehouse RH (1970) Standards for children's height at ages 2–9 years allowing for height of parents. Arch Dis Child 45: 755–762
Molinari L, Largo RH, Prader A (1985) Target height and secular trend in the Swiss population. In: J Borms et al. (eds) Human growth and development. Plenum, New York, pp 193–200
Trygstad CW, Mangos JA, Bloodworth JMB, Lobeck CC (1969) A sibship with Bartter's syndrome: failure of total adrenalectomy to correct the potassium wasting. Pediatrics 44: 234–242
James T, Holland NH, Preston D (1975) Bartter syndrome: typical facies and normal plasma volume. Am J Dis Child 129: 1205–1207
McCredia DA, Rotenberg E, Williams AL (1974) Hypercalciuria in potassium-losing nephropathy: a variant of Bartter's syndrome. Aust J Med 10: 286–295
Girardin E, Favre L, Vallotton MB, Paunier L (1986) Familial Bartter's syndrome: report of a case with early manifestations and persistent hypercalciuria. Helv Paediatr Acta 41: 221–228
West CD, Smith WC (1956) An attempt to elucidate the cause of growth retardation in renal disease. Am J Dis Child 91: 460–467
Uttley WS, Paxton J, Thistlethwaite (1972) Urinary concentrating ability and growth failure in urinary tract disorders. Arch Dis Child 47: 436–441
Shoemaker L, Welch TR, Bergstrom W, Abrams A, Yergey AL, Viera N (1993) Calcium kinetics in the hyperprostaglandin E syndrome. Pediatr Res 33: 92–96
Albertsson-Wikland K, Karlberg J (1994) Natural growth in children born small for gestational age with and without catch-up growth. Acta Paediatr [Suppl] 399: 64–70
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seidel, C., Reinalter, S., Seyberth, H.W. et al. Pre-pubertal growth in the hyperprostaglandin E syndrome. Pediatr Nephrol 9, 723–728 (1995). https://doi.org/10.1007/BF00868723
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00868723