Abstract
One hundred and thirty seven isolates ofCandida species were isolated from antiobiotic associated diarrhoea cases and were examined to study the role ofCandida in the pathogenesis of diarrhoea in infants. The quantitative estimation of yeast population by simple gram stain smear revealed more than 70% of the cases had 3+ score. The isolates further screened for detection ofβ-lactamases. Among the isolatedCandida sp,β-lactamases was secreted byC. albicans, C. tropicalis, C. krusei andC. parapsilosis. Further, 46% of theCandida isolates were found to be produced 741–1110 mU/ml ofβ-lactamases, suggesting that these enzyme would inactivate penicillin group of drugs and cause failure in the therapy directed against other diarrhoegenic bacteria.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- AAD:
-
antibiotic associated diarrhoea
References
Gorbach SL. Bacterial diarrhoea and its treatment. Lancet 1987; 241: 1378–1381.
Acar JF, Kitzis MD, Gutmann L. The incidence ofβ-lactamase producing pathogens. APMIS 1989; suppl. 5: 2–8
Mehta RJ, Nash CH.β-lactamases activity in yeasts. J Antibiotics 1978; 31: 239–240.
Danna LP, Utban C, Bellin E, Rahal JJ. Role ofCandida in pathogenesis of antibiotic associated diarrhoea in elderly inpatients. Lancet 1991; 337: 511–514.
Sally JT, Witebsky FG.β-lactamase detection in nineStaphylococcal species. J Clin Microbiol 1984; 20(6): 1200–1201.
Rolfe RD, Finegold DM. Intestinalβ-lactamase activity in amphicillin inducedCl. difficle associated illeocitis. J Infec Dis 1983; 147(2): 227–235.
Kaplan LJ, Flaherty J. Secretary diarrhoea andCandidal over growth; cause and effect. J Infect Dis 1991; 164: 823–824.
Holti G. Symposium onCandida infections. Edinburgh, Scotland. Livingstone, p. 73.
Kane JG, Chrestein JH, Garagusi VF. Diarrhoea caused byCandida. Lancet 1976; 1: 335–336.
Talwar P, Chakrabarti A, Mehta S, Walia BNS, Kumar L, Chugh KS. Fungal diarrhoea: association of different fungi and seasonal variation in their incidence. Mycopathologia 1990; 110: 102–105.
O Brien TF. Resistance of bacteria to antibacterial agents: report of task force. Rev Infect Dis 1987; 9(3): 244–260.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ponnuvel, K.M., Rajkumar, R., Menon, T. et al. Role ofCandida in indirect pathogenesis of antibiotic associated diarrhoea in infants. Mycopathologia 135, 145–147 (1996). https://doi.org/10.1007/BF00632335
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00632335