Abstract
Normal serum creatinine (Scr) and creatinine clearance (Ccr) values during the first 10 days of life were obtained in 63 very premature (28–32 weeks of gestation), premature (33–37 weeks) and term infants (38–42 weeks). Scr fell, and Ccr rose less markedly in the very premature infants. Scr was 80 μmol/l on the 1st day of life both in very premature and premature infants, and 77 μmol/l in full-term neonates. After 10 days, Scr was 73, 53 and 35 μmol/l respectively. There was an exponential correlation between Ccr and gestational age, indicating rapid maturation of glomerular function.
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Abbreviations
- Scr:
-
serum creatinine
- Ccr:
-
creatinine clearance
- GA:
-
gestational age
- GFR:
-
glomerular filtration rate
References
Aperia A, Broberger O, Elinder G, Herin P, Zetterström R (1981) Postnatal development of renal function in preterm and full-term infants. Acta Paediatr Scand 70:183–187
Assadi FK, John EG, Fornell L, Rosenthal IM (1985) Falsely elevated serum-creatinine concentration in ketoacidosis. J Pediatr 107:562–566
Bartels H, Böhmer M, Heierli C (1972) Serum-Kreatinin-Bestimmung ohne Enteiweißen. Clin Chim Acta 37:193–197
Bauer JH, Brocks CS, Burch RN (1982) Clinical appraisal of creatinine-clearance as a measurement of glomerular filtration rate. Am J Kidney Dis 2:337–341
Bowers LD (1980) Kinetic serum creatinine assays: the role of various factors in determining specificity. Clin Chem 26:551–554
Carrie BJ, Golbetz HV, Michaels AB, Myers BD (1980) Creatinine: an inadequate filtration marker in glomerular disease. Am J Med 69:177–182
Dubowitz LMS, Dubowitz V, Goldberg C (1970) Clinical assessment of gestational age in the newborn infant. J Pediatr 77:1–10
Fawer CL, Torrado A, Guignard JP (1979) Maturation of renal function in full-term and premature infants. Helv Paediatr Acta 34:11–121
Feldman H, Guignard JP (1982) Plasma creatinine in the first month of life. Arch Dis Child 57:123–126
Goldmann R, Yadley RA, Nourok DS (1967) Comparison of endogenous and exogenous creatinine-clearance in man. Proc Soc Exp Biol Med 126:1611–1614
Guignard JP, Torrado A, Da Cunha A, Gautier E (1975) Glomerular filtration rate in the first three weeks of life. J Pediatr 87:268–272
Husdan H, Rapaport A (1968) Estimation of creatinine by the Jaffe reaction: a comparison of three methods. Clin Chem 14:222–238
Lebel RR, Gutmann FD, Mazumdan DC, Grzgs U (1984) Creatinine determination in ketosis. N Engl J Med 310:1671
Moril, Javoie T (1983) Negative ketone interference with kinetic discrete analyzer KDA. Clin Chem 29:733–734
Oh W (1981) Renal function and clinical disorders in the neonate. Clin Perinatol 8:215–223
Ross B, Cowett RM, Oh W (1977) Renal function of low birth weight infants during the first two months of life. Pediatr Res 11: 1162–1164
Schwartz GJ, Haycock GB (1976) Plasma creatinine and urea concentrations in children. J Pediatr 88:828–830
Sertel H, Scopes J (1973) Rates of creatinine clearance in babies less than a week of age. Arch Dis Child 48:717–720
Shemesh O, Golbetz H, Kriss JP, Myers BD (1985) Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 28:830–838
Siegel SR, Oh W (1976) Renal function as a marker of human fetal maturation. Acta Paediatr Scand 65:481–485
Stonestreet BS, Oh W (1975) Plasma creatinine in low birth weight infants during the first three months of life. Pediatrics 61: 788–789
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Gordjani, N., Burghard, R., Leititis, J.U. et al. Serum creatinine and creatinine clearance in healthy neonates and prematures during the first 10 days of life. Eur J Pediatr 148, 143–145 (1988). https://doi.org/10.1007/BF00445923
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DOI: https://doi.org/10.1007/BF00445923