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References
Rossini AA, Mordes JP, Like AA (1984) Animal models of insulin-dependent diabetes mellitus. In: Immunology in diabetes. Andreani D, DiMario U, Federlin KF, Heding LG (eds) Kimpton, London, pp 35–44
Bottazzo GF (1984) β-cell damage in diabetic insulitis: are we approaching a solution? Diabetologia 26: 241–249
Eisenbarth GS (1986) Type 1 diabetes mellitus. A chronic autoimmune disease. N Engl J Med 314: 1360–1368
Notkins AL, Yoon JW (1984) Virus-induced diabetes mellitus. In: Concepts in viral pathogenesis. Notkins AL, Oldstone MBA (eds) Springer, New York, pp 241–247
Toniolo A, Onodera T (1984) Viruses and diabetes. In: Immunology in diabetes. Andreani D, DiMario U, Federlin KF, Heding LG (eds) Kimpton, London, pp 71–93
Bottazzo GF, Pozzilli P, Mirakian R, Dean BM, Doniach D (1984) Early immunological events in diabetes. In: Immunology in diabetes. Andreani D, DiMario U, Federlin KF, Heding LG (eds) Kimpton, London, pp 95–104
Rossini AA, Mordes JP, Like AA (1985) Immunology of insulin-dependent diabetes mellitus. Ann Rev Immunol 3: 289–320
Nerup J, Lernmark A, Scott J (1984) Autoimmunity. In: Immunology of clinical and experimental diabetes. Gupta S (ed) Plenum, New York, pp 351–367
Irvine WJ (1980) Autoimmunity and diabetes. In: Autoimmune aspects of endocrine disorders. Pinchera A, Doniach D, Fenzi GF, Baschieri L (eds) Academic Press, London, pp 249–274
Handwerger BS (1985) The immunology of diabetes mellitus. In: Autoimmunity and endocrine disease. Volpe R (ed) Marcel Dekker, New York, pp 287–344
Dobersen MJ (1985) Humoral autoimmune aspects of insulin-dependent (Type 1) diabetes mellitus. Concepts Immunopathol 2: 47–64
Papadopoulos GK, Lernmark A (1983) The spectrum of islet cell antibodies. In: Autoimmune endocrine disease. Davies TF (ed) Wiley, New York, pp 167–180
Herold KC, Huen AH-J, Rubenstein AH, Lernmark A (1984) Humoral abnormalities in type 1 (insulin-dependent) diabetes mellitus. In: Immunology in diabetes. Andreani D, DiMario U, Federlin KF, Heding LG (eds) Kimpton, London, pp 105–120
Dobersen MJ, Scharff JE, Ginsberg-Fellner F, Notkins AL (1980) Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus. N Engl J Med 303: 1493–1498
Eisenbarth GS, Morris MA, Scearce RM (1981) Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus. J Clin Invest 67: 403–408
Brogren CH, Lernmark A (1982) Islet cell antibodies in diabetes. Clin Endocrinol Metab 11: 409–430
Huen AH-J, Haneda M, Freedman Z, Lernmark A, Rubenstein AH (1983) Quantitative determination of islet cell surface antibodies using 125I-protein A. Diabetes 32: 460–465
Kolb H, Stroheker M, Biener J, Gruneklee D, Muntefering H, Gries FA (1980) Analysis of the persistence of islet cell antibodies and islet cell type-specific antibodies in type 1 diabetic children. In: Autoimmune aspects of endocrine disease. Pinchera A, Doniach D, Fenzi GF, Baschieri L (eds) Academic Press, London, pp 291–294
Riley W, Maclaren N (1984) Islet cell antibodies are seldom transient. Lancet 1: 1351–1352
Irvine WJ, McCallum CJ, Gray RS, Campbell CJ, Duncan LJP, Farquhar JW, Vaughan H, Morris PJ (1977) Pancreatic islet-cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune disease, and HLA type. Diabetes 26: 138–147
Bright GM, Blizzard RM, Kaiser DL, Clarke WL (1982) Organ-specific autoantibodies in children with common endocrine diseases. J Pediatr 100: 8–14
Del Prete GF, Betterle C, Padovan D, Erle G, Toffolo A, Bersahi G (1977) Incidence and significance of islet-cell autoantibodies in different types of diabetes mellitus. Diabetes 26: 909–915
Rodger B, Whittmgham S, Martin FIR, Hawkins BR, Dawkins RL, Welborn TA (1980) A population survey of pancreatic islet cell antibodies. Clin Exp Immunol 39: 125–129
Lendram R, Walker G, Cudworth AG, Theophanides C, Pyke DA, Bloom A, Gamble DR (1976) Islet-cell antibodies in diabetes mellitus. Lancet 2: 1273–1276
Gorsuch AN, Lister J, Dean BM, Spencer KN, McNally JM, Bottazzo GF, Cudworth AG (1981) Evidence for a long prediabetic period in type 1 (insulin-dependent) diabetes mellitus. Lancet 2: 1363–1365
Srikanta S, Ganda OP, Eisenbarth GS, Soeldner JS (1983) Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for type 1 diabetes mellitus. N Engl J Med 308: 322–325
Mustonen A, Knip M, Huttunen N-P, Puukka R, Kaar M-L, Akerblom HK (1984) Evidence of delayed β-cell destraction in type 1 (insulin-dependent) diabetic patients with persisting complement-fixing cytoplasmic islet cell antibodies. Diabetologia 27: 421–426
Ginsberg-Fellner F, Witt ME, Franklin BH, Yagihashi S, Toguchi Y, Dobersen MJ, Rubenstein P, Notkins AL (1985) Triad of markers for identifying children at high risk of developing insulin-dependent diabetes mellitus. J Am Med Assoc 254: 1469–1472
Irvine WJ (1980) Immunological aspects of diabetes mellitus: a review. (1980) In: Immunology of diabetes. Irvine WJ (ed) Teviot, Edinburgh, pp 1–53
Nerup J, Lernmark A (1981) Autoimmunity in insulin-dependent diabetes mellitus. Am J Med 70: 135–141
Maclaren NK, Riley WJ (1985) Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Diabetes Care 8 [Suppl 1]: 34–38
Bottazzo GF, Mann JI, Thorogood M, Baum JD, Doniach D (1978) Autoimmunity in juvenile diabetics and their families. Br Med J 2: 165–168
Notsu K, Oka N, Note S, Nabeya N, Kuno S, Sakurami T (1985) Islet cell antibodies in the Japanese population and subjects with Type-1 (insulin-dependent) diabetes. Diabetologia 28: 660–662
Toguchi Y, Ginsberg-Fellner F, Rubenstein P (1985) Cytotoxic islet cell surface antibodies (ICSA) in patients with Type 1 diabetes and their first-degree relatives. Diabetes 34: 855–860
Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark A (1982) Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet-cell proteins. Nature 298: 167–169
Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337–1339
Karjalainen J, Knip M, Mustonen A, Ilonen J, Akerblom HK (1986) Relation between insulin antibody and complement-fixing islet cell antibody at clinical diagnosis of IDDM. Diabetes 35: 620–622
Wilkin T, Armitage M, Casey C, Pyke DA, Hoskins PJ, Rodier M, Diaz JL, Leslie RDG (1985) Value of insulin autoantibodies as serum markers for insulin-dependent diabetes mellitus. Lancet 1: 480–482
Arslanian SA, Becker DJ, Rabin B, Atchison R, Eberhardt M, Cavender D, Dorman J, Drash AL (1985) Correlates of insulin antibodies in newly diagnosed children with insulin-dependent diabetes before insulin therapy. Diabetes 34: 926–930
McEvoy RC, Witt ME, Ginsberg-Fellner F, Rubinstein P (1986) Anti-insulin antibodies in children with type 1 diabetes mellitus. Genetic regulation of production and presence at diagnosis before insulin replacement. Diabetes 35: 634–641
Maclaren NK, Huang S-W, Fogh J (1975) Antibody to cultured human insulinoma cells in insulin-dependent diabetes. Lancet 1: 997–1000
Maron R, Elias D, de Jongh BM, Braining GJ, van Rood JJ, Schechter Y, Cohen IR (1983) Autoantibodies to the insulin receptor in juvenile onset insulin-dependent diabetes. Nature 303: 817–818
Schopfer K, Matter L, Tenschert R, Bauer S, Zuppinger K (1984) Anti-glucagon-cell and anti-adrenal-medullary-cell antibodies in islet-cell-autoantibody-positive diabetic children. N Engl J Med 310: 1536–1537
Bottazzo GF, Lendram R (1976) Separate autoantibodies to human pancreatic glucagon and somatostatin cells. Lancet 2: 873–876
Serjeantson S, Theophilus J, Zimmet P, Court J, Crossley JR, Elliott RB (1981) Lymphocytotoxic antibodies and histocompatibility antigens in juvenile-onset diabetes mellitus. Diabetes 30: 26–29
Srikanta S, Malaviya AN, Mehra NK, Vaidya MC, Geevarghese PJ, Ahuja MMS (1981) Autoimmunity in type 1 (insulin-dependent) diabetes mellitus in North India. J Clin Immunol 1: 169–173
Nagaoka K, Sakurami T, Nabeya N, Imura H, Kuno S (1979) Antimicrosomal antibodies, gastric parietal cell antibodies and antinuclear factors in insulin-dependent diabetes mellitus. Endocrinol Jpn 26: 599–603
Dorchy H, Lemiere B, Toussaint D, Gausset P (1981) Anticorps anticellules des ilots de Langerhans et specifiques d'organes chez les jeunes diabetiques. Nouv Presse Med 10: 2795–2798
Goldstein E, Drash A, Gibbs J, Blizzard RM (1970) Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue. J Pediatr 77: 304–306
Nerup J, Binder C (1973) Thyroid, gastric and adrenal auto-immunity in diabetes mellitus. Acta Endocrinol 72: 279–286
Kokkonen J, Kiuttu J, Mustonen A, Rasanen O (1982) Organ-specific antibodies in healthy and diabetic children and young adults. Acta Paediatr Scand 71: 223–226
Betterle C, Zanette F, Pedini B, Presotto F, Rapp LB, Monciotti CM, Rigon F (1984) Clinical and subclinical organ-specific autoimmune manifestations in Type 1 (insulin-dependent) diabetic patients and their first-degree relatives. Diabetologia 26: 431–436
Irvine WJ, Scarth L, Clarke BF, Cullen R, Duncan LJP (1970) Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet 2: 163–168
Neufeld M, Maclaren NK, Riley WJ, Lezotte D, McLaughlin JV, Silverstein J, Rosenbloom AL (1980) Islet cell and other organ-specific antibodies in US Caucasians and Blacks with insulin-dependent diabetes mellitus. Diabetes 29: 589–592
Whittingham S, Mathews JD, Mackay IR, Stocks AE, Ungar B, Martin FIR (1971) Diabetes mellitus, autoimmunity and ageing. Lancet 1: 763–767
Ketchum CH, Riley WJ, Maclaren NK (1984) Adrenal dysfunction in asymptomatic patients with adrenocortical autoantibodies. J Clin Endocrinol Metab 58: 1166–1170
Ungar B, Stocks AE, Martin FIR, Whittingham S, Mackay IR (1968) Intrinsic-factor antibody, parietal-cell antibody, and latent pernicious anaemia in diabetes mellitus. Lancet 2: 415–418
Simkins S (1968) Antithyroglobulin antibodies in diabetes mellitus. Diabetes 17: 136–140
Bliddal H, Bech K, Johansen K, Nerup J (1984) Thyroid-stimulating immunoglobulins in insulin-dependent diabetes mellitus. Eur J Clin Invest 14: 474–478
Mirakian R, Bottazzo GF, Cudworth AG, Richardson CA, Doniach D (1982) Autoimmunity to anterior pituitary cells and the pathogenesis of insulin-dependent diabetes mellitus. Lancet 1: 755–759
Sugiura M, Hashimoto A, Shizawa M, Tsukada M, Maruyama S, Ishido T, Kasahara T, Hirata Y (1986) Heterogeneity of anterior pituitary cell antibodies detected in insulin-dependent diabetes mellitus and adrenocorticotropic hormone deficiency. Diabetes Res 3: 111–114
Rousset B, Vialettes B, Bernier-Valentin F, Vaque P, Mornex R (1984) Anti-tubulin antibodies in recent onset type 1 (insulin-dependent) diabetes mellitus: comparison with islet cell antibodies. Diabetologia 27: 427–432
Menser MA, Hudson JR (1983) Pancreatic islet and other auto-antibodies in juvenile and adult onset diabetics in Australia. Pathology 15: 309–313
Notsu K, Note S, Nabeya N, Kuno S, Sakurami T (1983) Antinuclear antibodies in childhood diabetics. Endocrinol Jpn 30: 469–473
Huang S-W, Haedt LH, Rich S, Barbosa J (1981) Prevalence of antibodies to nucleic acids in insulin-dependent diabetics and their relatives. Diabetes 30: 873–874
Banatvala JE, Schernthaner G, Schober E, De Silva LM, Bryant J, Borkenstein M, Brown D, Menser MA, Silink M (1985) Coxsackie B, mumps, rubella, and cytomegalovirus specific IgM responses in patients with juvenile-onset insulin-dependent diabetes mellitus in Britain, Austria, and Australia. Lancet 1: 1409–1412
Frisk G, Fohlman J, Kobbah M, Ewald U, Tuvemo T, Diderholm H, Friman G (1985) High frequency of Coxsackie-B-virus-specific IgM in children developing type 1 diabetes during a period of high diabetes morbidity. J Med Virol 17: 219–227
Wardle EN (1978) An antibody to low density lipoprotein in diabetics. Experientia 34: 886–887
Di Mario U, Irvine WJ, Guy K, Borsey DQ, Iavicoli M, Ventriglia L (1983) Circulating immune complexes in diabetics: the influence of sex, age, duration of disease and type of treatment. J Clin Lab Immunol 11: 17–20
Ludwig H, Schernthaner G, Tappeiner G, Mayr WR, Freyler H (1980) Circulating immune complexes in insulin-dependent diabetes: analysis of incidence of islet cell antibodies, insulin antibodies, HLA antigens, duration of disease and stages of diabetic retinopathy. In: Autoimmune aspects of endocrine disease. Pinchera A, Doniach D, Fenzi GF, Baschieri L (eds) Acad Press, London, pp 313–318
Delespesse G, Gansset P, Sarfati M, Dubi-Rucquoy M, Debisschop M-J, van Haelst L (1980) Circulating immune complexes in old people and in diabetics: correlation with autoantibodies. Clin Exp Immunol 40: 96–102
Freedman ZR, Feek CM, Irvine WJ, Lernmark A, Rubenstein AH, Steiner DF, Huen A (1976) Islet cell cytoplasmic and cell surface antibodies in diabetes mellitus. Trans Assn Amer Phys 96: 64–76
Dobersen MJ, Bell AM, Jenson AB, Notkins AL, Ginsberg-Fellner F (1979) Detection of antibodies to islet cells and insulin with paraffin-embedded pancreas as antigen. Lancet 2: 1078
Assa S, Karp M, Erster B, Laron Z (1985) Cytoplasmic islet cell antibodies in type 1 diabetics in Israel and their first-degree relatives. Isr J Med Sci 21: 727–730
Marner B, Agner T, Binder C, Lernmark A, Nerup J, Mandrup-Poulsen T, Walldorff S (1985) Increased reduction in fasting C-peptide is associated with islet cell antibodies in type-1 (insulin-dependent) diabetic patients. Diabetologia 28: 875–880
Borsey DQ, Di Mario U, Irvine WJ, Gray RS, Guy K, Weston J, Peutherer J, Duncari LJP (1983) Humoral immunity in type 1 diabetes mellitus: a prospective study. J Clin Lab Immunol 11: 9–15
Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14: 619–633
Foulis AK, Stewart JA (1984) The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis, and associated changes in the endocrine acinar tissue. Diabetologia 26: 456–461
Rodier M, Andary M, Richard JL, Mirouze J, Clot J (1984) Peripheral blood T-cell subsets studied by monoclonal antibodies in type 1 (insulin-dependent) diabetes: effect of blood glucose control. Diabetologia 27: 136–138
Herold KC, Huen A, Gould L, Traisman H, Rubenstein AH (1984) Alterations in lymphocyte subpopulations in type 1 (insulin-dependent) diabetes mellitus: exploration of possible mechanisms and relationships to autoimmune phenomena. Diabetologia 27: 102–105
Mascart-Lemone F, Delespesse G, Dorchy H, Lemiere B, Servais G (1982) Characterization of immunoregulatory Tlymphocytes in insulin-dependent diabetic children by means of monoclonal antibodies. Clin Exp Immunol 47: 296–300
Galluzzo A, Giordano C, Rubino G, Bompiani GD (1984) Immunoregulatory T-lymphocyte subset deficiency in newly diagnosed type 1 (insulin-dependent) diabetes mellitus. Diabetologia 26: 426–430
Buschard K, Ropke C, Madsbad S, Mehlsen J, Rygaard J (1983) Tlymphocyte subsets in patients with newly diagnosed type 1 (insulin-dependent) diabetes: a prospective study. Diabetologia 25: 247–251
Horita M, Suzuki H, Onodera T, Ginsberg-Fellner F, Fauci AS, Notkins AL (1982) Abnormalities of immunoregulatory T cell subsets in patients with insulin-dependent diabetes mellitus. J Immunol 129: 1426–1429
Hayward AR, Herberger M (1984) Culture and phenotype of activated T-cells from patients with type-1 diabetes mellitus. Diabetes 33: 319–323
Jackson RA, Morris MA, Haynes BF, Eisenbarth GS (1982) Increased circulating la-antigen-bearing T cells in type 1 diabetes mellitus. N Engl J Med 306: 785–788
Ilonen J, Surcel H-M, Mustonen A, Kaar M-L, Akerblom HK (1984) Lymphocyte subpopulations at the onset of type-1 (insulin-dependent) diabetes. Diabetologia 27: 106–108
Chandy KG, Charles MA, Buckingham B, Waldeck N, Kershnar A, Gupta S (1984) Deficiency of monoclonal antibody (Leu 7) defined NK cells in newly diagnosed insulin-dependent diabetes mellitus. Immunol Lett 8: 89–91
Alviggi L, Hoskins PJ, Pyke DA, Johnston C, Tee DEH, Leslie RDG, Vergani D (1984) Pathogenesis of insulin-dependent diabetes: a role for activated T lymphocytes. Lancet 2: 4–6
Zier KS, Leo MM, Spielman RS, Baker L (1984) Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. Diabetes 33: 552–555
Nerup J, Andersen OO, Bendixen G, Egeberg J, Poulsen JE (1973) Antipancreatic, cellular hypersensitivity in diabetes mellitus: antigenic activity of fetal calf pancreas and correlation with clinical type of diabetes. Acta Allergol 28: 223–230
MacCuish AC, Jordan J, Campbell CJ, Duncan LJP, Irvine WJ (1974) Cell-mediated immunity to human pancreas in diabetes mellitus. Diabetes 23: 693–697
Topliss D, How J, Lewis M, Row V, Volpe R (1983) Evidence for cell-mediated immunity and specific suppressor T lymphocyte dysfunction in Graves' disease and diabetes mellitus. J Clin Endocrinol Metab 57: 700–705
Mori Y, Matsuda I, Tsuruoka A, Sasaki A, Utsunomiya K Ishii K, Yamada H, Tanese T, Ishikawa H, Suko M, Shida T, Ikeda Y (1985) Cellular hypersensitivity to human pancreatic B-cell clone in diabetes mellitus and its relationship to the presence of islet cell antibodies. Endocrinol Jpn 32: 497–504
Gupta S, Fikrig S, Orti E (1983) Autologous mixed lymphocyte reaction in man VI. Deficiency of autologous mixed lymphocyte reaction in type 1 (insulin-dependent) diabetes mellitus. J Clin Lab Immunol 11: 59–62
Delespesse G, Duchateau J, Bastenie PA, Lauvaux JP, Collet H, Govaerts A (1974) Cell-mediated immunity in diabetes mellitus. Clin Exp Immunol 18: 461–467
MacCuish AC, Jordan J, Campbell CJ, Duncan LJP, Irvine WJ (1975) Cell-mediated immunity in diabetes mellitus. Lymphocyte transformation by insulin and insulin fragments in insulin-treated and newly-diagnosed diabetics. Diabetes 24: 36–43
Nell L, Thomas JW (1983) The human immune response to insulin. I. Kinetic and cellular aspects of lymphocyte proliferative responses in diabetics. J Immunol 131: 701–705
Kurtz AB, Di Silvio L, Lydyard P (1985) Lymphocyte proliferation as a test of the immune response to insulin in diabetics. Diabetes Res 2: 175–178
Bagdade JD, Nielson KL, Bulger RJ (1972) Reversible abnormalities in phagocytic function in poorly controlled diabetic patients. Am J Med Sci 263: 451–456
Berken A, Sherman AA (1974) Reticuloendothelial system phagocytosis in diabetes mellitus. Diabetes 23: 218–220
Pozzilli P, Gorsuch A, Sensi M., Bottazzo GF, Cudworth AG (1979) Evidence for raised K-cell levels in type-1 diabetes. Lancet 2: 173–175
Charles MA, Suzuki M, Waldeck N, Dodson LE, Slater L, Ong K, Kershnar A, Buckingham B, Golden M (1983) Immune islet killing mechanisms associated with insulin-dependent diabetes: in vitro expression of cellular and antibody-mediated islet cell cytotoxicity in humans. J Immunol 130: 1189–1194
Huang S-W, Maclaren NK (1976) Insulin-dependent diabetes: a disease of autoaggression. Science 192: 64–66
Selam JL, Clot J, Andary M, Mirouze J (1979) Circulating lymphocyte subpopulations in juvenile insulin-dependent diabetes: correction of abnormalities by adequate blood glucose control. Diabetologia 16: 35–40
Cacciari E, Masi M, Franceschi C, Cicognani A, Pirazzoli P, Licastro F, Fantini MP, Chiricolo M, Tassinari D (1980) Immunological abnormalities in juvenile onset diabetes. In: Autoimmune aspects of endocrine disease. Pinchera A, Doniach D, Fenzi GF, Baschieri L (eds) Acad Press, London, pp 329–332
Plouffe JF, Silva J Jr, Fekety R, Alien JL (1978) Cell-mediated immunity in diabetes mellitus. Infect Immun 21: 425–429
Lederman MM, Ellner JJ, Rodman HM (1981) Defective suppressor cell generation in juvenile onset diabetes. J Immunol 127: 2051–2055
MacCuish AC, Urbaniak SJ, Campbell CJ, Duncan LJP, Irvine WJ (1974) Phytohemagglutinin transformation and circulating lymphocyte subpopulations in insulin-dependent diabetic patients. Diabetes 23: 708–712
Fairchild RS, Kyner JL, Abdou NI (1982) Specific immunoregulation abnormality in insulin-dependent diabetes mellitus. J Lab Clin Med 99: 175–186
Jaworski MA, Colle E, Guttmann RD (1983) Abnormal immunoregulation in patients with insulin dependent diabetes mellitus and their healthy first degree relatives. Hum Immunol 7: 25–34
Buschard K, Madsbad S (1984) A longitudinal study of virus antibodies in patients with newly diagnosed type 1 (insulin dependent) diabetes mellitus. J Clin Lab Immunol 13: 65–70
Buschard K, Madsbad S, Rygaard J (1980) Depressed suppressor cell activity in patients with newly diagnosed insulin-dependent diabetes mellitus. Clin Exp Immunol 41: 25–32
Rerup CC (1970) Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 22: 485–518
Cooperstein SJ, Watkins D (1981) Action of toxic drugs on islet cells. In: The islets of Langerhans. Cooperstein SJ, Watkins D (eds) Academic Press, New York, pp 387–425
Naji A, Barker CF (1984) Animal models of human type 1 diabetes. In: Immunology of clinical and experimental diabetes. Gupta S (ed) Plenum, New York, pp 91–112
Boitard C, Debray-Sachs M, Bach JF (1986) Autoimmune disorders in diabetes. Adv Nephrol 15: 281–305
Pasko KL, Salvin SB, Winkelstein A (1981) Mechanisms in the in vivo release of lymphokines. V. Responses in alloxan-treated and genetically diabetic mice. Cell Immunol 62: 205–219
Pavelic K, Slijepcevic M, Pavelic J (1978) Recovery of immune system in diabetic mice after treatment with insulin. Horm Metab Res 10: 381–386
Ptak W, Czarnik Z, Hanczakowska M (1975) Contact sensitivity in alloxan-diabetic mice. Clin Exp Immunol 19: 319–325
Roth MD, Barg M, Michalski R, Arquilla ER (1980) Cell-mediated immunity in chronically diabetic mice. Diabetes 29: 825–829
Mahmoud AAF, Rodman HM, Mandel MA, Warren KS (1976) Induced and spontaneous diabetes mellitus and suppression of cell-mediated immunologic responses. Granuloma formation, delayed dermal reactivity, and allograft rejection. J Clin Invest 57: 362–367
Ptak W, Hanczakowska M, Rozycka R, Rozycka D (1977) Impaired antibody responses in alloxan diabetic mice. Clin Exp Immun 29: 140–146
Gaulton GN, Schwartz JL, Eardley DD (1985) Assessment of the diabetogenic drags alloxan and streptozotocin as models for the study of immune defects in diabetic mice. Diabetologia 28: 769–775
Drachman RH, Root RK, Wood WB Jr (1966) Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defense. I. Demonstration of a defect in phagocytosis. J Exp Med 124: 227–240
Weir DM, Blackwell CC, McLean CA (1981) Impaired bacterial binding to peritoneal exudate cells from mice with alloxan induced diabetes. J Clin Lab Immunol 5: 37–40
Pallavicini MG, Nichols WK (1976) Inhibition of lymphocyte blastogenesis by factor(s) in alloxan-diabetic rat plasma. Diabetes 25: 614–622
Nevalainen DE, Hoftiezer V (1977) The response of C3H mice to streptozotocin. I.Thymic depression and leukocyte toxicity. Am J Med Technol 43: 417–418
Nichols WK, Spellman JB, Vann LL, Daynes RA (1979) Immune responses of diabetic animals: direct immunosuppressant effects of streptozotocin in mice. Diabetologia 16: 51–57
Nichols WK, Vann LL, Spellman JB (1981) Streptozotocin effects on T lymphocytes and bone marrow cells. Clin Exp Immunol 46: 627–632
Ishabashi T, Kitahara Y, Harada Y, Harada S, Takamoto M, Ishibashi T (1980) Immunologic features of mice with streptozotocin-induced diabetes. Depression of their immune responses to sheep red blood cells. Diabetes 29: 516–523
Chi DS, Berry DL, Dillon KA, Arbogast BW (1982) Inhibition of in vitro lymphocyte response by streptozotocin-induced diabetic rat serum: a function of very-low-density lipoproteins. Diabetes 31: 1098–1104
Saiki O, Negoro S, Tsuyuguchi I, Yamamura Y (1980) Depressed immunological defense mechanisms in mice with experimentally induced diabetes. Infect Immun 28: 127–131
Handwerger BS, Fernandes G, Riehm T, Sutherland DER, Brown DM (1984) Alterations in immunological function in streptozotocin-induced murine diabetes mellitus: correction by islet cell transplantation. Clin Immunol Immunopathol 32: 275–284
Kitahara Y, Ishibashi T, Harada Y, Takamoto M, Tanaka K (1981) Reduced resistance to Pseudomonas septicaemia in diabetic mice. Clin Exp Immunol 43: 590–598
Rhodes J (1975) Modulation of macrophage Fc receptor expression in vitro by insulin and cyclic nucleotides. Nature 257: 597–599
Lima AO, Queiroz M, Brascher HM, Vargens J (1979) Effect of insulin on immunological phagocytosis by macrophages. Experientia 35: 119–120
Kragballe K, Beck-Nielsen H, Pedersen O, Ellegaard J, Sorensen NS (1981) Monocyte-mediated antibody-dependent cytoxicity. Modulation by glycolysis and insulin. Scan J Haematol 26: 137–144
Bar RS, Kahn CR, Koren HS (1977) Insulin inhibition of antibody-dependent cytotoxicity and insulin receptors in macrophages. Nature 265: 632–634
Snow EC, Feldbush TL, Oaks JA (1980) The role of insulin in the response of murine T lymphocytes to mitogenic stimulation in vitro. J Immunol 124: 739–744
Kumagai J-I, Akiyama H, Iwashita S, Iida H, Yahara I (1981) In vitro regeneration of resting lymphocytes from stimulated lymphocytes and its inhibition by insulin. J Immunol 126: 1249–1254
Helderman JH (1981) Role of insulin in the intermediary metabolism of the activated thymic-derived lymphocyte. J Clin Invest 67: 1636–1642
Diaz-Espada F, Lopez-Alarcon L (1982) Mitogen-induced changes in glycolytic enzymes of mouse lymphocytes: influence of insulin on cell activation in vitro. Immunology 46: 705–712
Strom TB, Bangs JD (1982) Human serum-free mixed lymphocyte response: the stereospecific effect of insulin and its potentiation by transferrin. J Immunol 128: 1555–1559
Snow EC, Feldbush TL, Oaks JA (1981) The effect of growth hormone and insulin upon MLC responses and the generation of cytotoxic lymphocytes. J Immunol 126: 161–164
Strom TB, Bear RA, Carpenter CB (1975) Insulin-induced augmentation of lymphocyte-mediated cytotoxicity. Science 187: 1206–1208
Helderman JH, Strom TB (1977) Emergence of insulin receptors upon alloimmune T cells in the rat. J Clin Invest 59: 338–344
Hunt P, Eardley DD (1986) Suppressive effects of insulin and insulin-like growth factor-1 (IGF1) on immune responses. J Immunol 136: 3994–3999
Krug U, Krug F, Cuatrecasas P (1972) Emergence of insulin receptors on human lymphocytes during in vitro transformation. Proc Natl Acad Sci USA 69: 2604–2608
Helderman JH, Strom TB (1979) Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes. J Biol Chem 254: 7203–7207
Hadden JW, Hadden EM, Wilson EE, Good RA, Coffey RG (1972) Direct action of insulin on plasma membrane ATPase activity in human lymphocytes. Nature New Biol 235: 174–177
Pavelic K, Vuk-Pavelic S (1981) Retarded growth of murine tumors in vivo by insulin- and glucagon-stimulated immunity and phagocytosis. J Nat Cancer Inst 66: 889–892
Bhakri HL, Jones H, Jones DA, Pettingale KW, Tee DEH (1983) T cell subpopulation dynamics following insulin-induced hypoglycemia in normal subjects. Clin Exp Immunol 53: 83–87
Notkins AL, Prabhakar BS (1986) Monoclonal autoantibodies that react with multiple organs: basis for reactivity. In: Autoimmunity, experimental and clinical aspects. Schwarte RS, Rose NR (eds) Ann NY Acad Sci 475: 123–124
Volpe R (1985) Autoimmune thyroid disease. In: Autoimmunity and endocrine disease. Volpe R (ed) Marcel Dekker, New York, pp 109–285
Shoenfeld Y, Schwartz RS (1984) Immunologic and genetic factors in autoimmune diseases. N Engl J Med 311: 1019–1029
Oldstone MBA, Notkins AL (1986) Molecular mimicry. In: Notkins AL, Oldstone MBA (eds) Concepts in viral pathogenesis II. Springer, New York, pp 195–202
Witzum JL, Steinbrecher UP, Kesaniemi YA, Fisher M (1984) Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus. Proc Natl Acad Sci USA 81: 3204–3208
Cohen MP (1986) Diabetes and Protein Glycosylation. Measurement and Biologic Relevance. Springer, New York, pp 1–168
Rimoin DL, Rotter JI (1984) The genetics of diabètes mellitus. In: Immunology in diabetes. Andreani D, DiMario U, Federlin KF, Heding LG (eds) Kimpton, London, pp 45–62
Dausset J, Hors J (1984) Immunogenetics of insulin-dependent juvenile diabetes. Diabetes Res 1: 115–123
Baker L, Kaye R, Root AW (1967) The early partial remission of juvenile diabetes mellitus. The roles of insulin and growth hormone. J Pediatr 71: 825–831
Hosker JP, Turner RC (1982) Insulin treatment of newly-presenting ketotic diabetic patients into the honeymoon period. Lancet 2: 633–635
Johansen K, Orskov H (1969) Plasma insulin during remission in juvenile diabetes mellitus. Br Med J 1: 676–678
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Drell, D.W., Notkins, A.L. Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30, 132–143 (1987). https://doi.org/10.1007/BF00274217
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DOI: https://doi.org/10.1007/BF00274217