Overall population N=30 | Control group N=15 | intravenous IG group N=15 | |
Age, years, median (Q1–Q3) | 10.6 (4–14.1) | 13.1 (4–14.1) | 7.1 (3.1–13.0) |
Weight, kg, median (Q1–Q3) | 35.0 (17–50) | 48.0 (7.8–56) | 35.0 (15–40) |
Sex, female, N (%) | 15 (50) | 9 (60) | 6 (40) |
PELOD-2 Score, median (Q1–Q3) | 6 (4–8) | 6 (4–7) | 6 (5–9) |
PIM-3, median (Q1–Q3) | 3.5 (1.9–939) | 3.2 (1.5–39.0) | 4.8 (2.2–51.3) |
Age-adjusted hypotension, N (%) | 18 (60) | 8 (53.3) | 10 (66.7) |
Fever>38.5°C, N* (%) | 7 (41) | 2 (33) | 5 (45.5) |
Vomiting, N (%) | 17 (57) | 7 (47) | 10 (67) |
Diarrhoea, N (%) | 17 (57) | 8 (53) | 9 (60) |
Neurological injury, N (%) | 9 (30) | 3 (20) | 6 (40) |
Muscular injury, N (%) | 13 (43) | 5 (33) | 8 (53) |
Cutaneous signs | |||
Desquamation, N (%) | 1 (3) | 1 (7) | 0 (0) |
Rash, N (%) | 25 (83) | 13 (87) | 12 (80) |
Skin necrosis, N (%) | 2 (7) | 1 (7) | 1 (7) |
Mucosal lesion, N (%) | 13 (43) | 6 (40) | 7 (47) |
Minimum leucocyte count (G/L), median (Q1–Q3) | 10.8 (8.1–14.1) | 11.11 (8.11–16.1) | 10.6 (6.6–12.7) |
Minimum lymphocyte count (G/L), median (Q1–Q3) (N=17) | 0.4 (0.2–0.7) | 0.44 (0.2–1.3) | 0.44 (0.3–0.7) |
Minimum platelet value (G/L), median (Q1–Q3) | 109.5 (84–143) | 96 (74–155) | 115 (94–143) |
Disseminated intravascular coagulation, N (%) | 11 (37) | 7 (47) | 4 (27) |
Liver alterations†, N (%) | 24 (80) | 11 (73) | 13 (87) |
Maximum creatinine value (µmol/L), median (Q1–Q3) | 99 (53–150) | 115 (39–147) | 79 (53–184) |
Maximum PCT value (µg/mL), median (Q1–Q3) (N=25) | 75 (54–122) | 71 (60–100) | 88 (50–300) |
Maximum lactate value (mmol/L), median (Q1–Q3) | 2.8 (2.3–40) | 2.8 (2.3–3.6) | 3.4 (2.4–4.3) |
Maximum CK value (UI/L), median (Q1–Q3) (N=21) | 353 (129–1283) | 336 (67–775) | 387 (295–1283) |
*N=26.
†Liver alterations were defined as: aspartate aminotransferase>3N or alanine aminotransferase>3N according to normal values for age or prothormbin ratio (PR)<70%
CK, creatine kinase; IG, immunoglobulin; PCT, procalcitonin; PELOD-2, Pediatric Logistic Organ Dysfunction-2; PIM 3, Pediatric Index of Mortality-3.