Table 1

Comparison of anthropometric and biochemical markers at baseline and most recent clinical review based on most recent phosphate level

	Serum phosphate abnormal			Serum phosphate normal			P value
	n=27			n=27
	Number	Median	IQR	Number	Median	IQR
At the commencement of treatment
Age (years)	27	7	2.3–10.0	27	9.6	7.1–11.7	0.01
Height (cm)	27	110.2	83.6–130.6	24	128.7	118.7–147.3	0.02
Height Z-score	27	−1.21	−2.70 to −0.62	24	−1.18	−2.00 to −0.65	0.31
Serum phosphate as a proportion of lower limit of normal for age	27	0.68	0.60–0.78	27	0.69	0.58–0.88	0.48
Serum calcium (mmol/L)	27	2.37	2.29–2.41	27	2.32	2.27–2.39	0.29
Serum PTH (pmol/L)	27	3.9	2.3–6.4	26	5.1	3.2–6.3	0.27
Serum ALP as a proportion of upper limit of normal for age	23	1.20	0.95–1.34	26	0.86	0.69–1.37	0.03
Serum 25-OH vitamin D (nmol/l)	9	89	65–106	13	66	55–82	0.32
TRP (%)	21	82	76–86	20	84	78–90	0.56
TmP/GFR as a proportion of lower limit of normal for age	21	0.54	0.43–0.70	20	0.59	0.49–0.70	0.79
At most recent review
Age (years)	27	10.4	5.6–12.7	27	13.5	9.7–16.5	<0.01
Height (cm)	26	126.2	106.4–146.2	25	144.0	132.8–161.4	0.02
Height Z-score	26	−1.4	−2.22 to −0.45	25	−0.87	−1.25 to −0.64	0.31
Serum phosphate as a proportion of lower limit of normal for age	27	0.86	0.82–0.94	27	1.12	1.07–1.23	<0.01
Serum calcium (mmol/L)	27	2.31	2.25–2.38	27	2.28	2.22–2.35	0.12
Serum PTH (pmol/L)	26	3.6	2.6–5.0	27	7.0	3.9–8.4	0.02
Serum ALP as a proportion of upper limit of normal for age	26	0.66	0.46–0.95	26	0.64	0.48–0.94	1.00
Serum 25-OH vitamin D (nmol/l)	23	92	72–126	23	71	57–109	0.03
TRP (%)	19	95	93–96	15	90	84–94	0.02
TmP/GFR as a proportion of lower limit of normal for age	19	0.95	0.75–1.09	15	1.11	0.96–1.36	0.02
Dose of burosumab (mg/kg)	28	1.33	1.03–1.74	25	0.93	0.70–1.27	<0.01
From onset of treatment to most recent review
Time (years)	27	0.0	2.6–3.6	27	0.0	2.5–3.8	0.32
Change in height (cm)	26	19.3	10.0–23.9	23	18.1	10.0–23.8	0.89
Change in height Z-score	26	0.22	−0.11 to 0.60	23	0.28	−0.19 to 0.50	0.87

ALP, alkaline phosphatase; PTH, parathyroid hormone; TmP/GFR, tubular maximum reabsorption rate of phosphate to glomerular filtration rate; TRP, tubular reabsorption of phosphate.