Adjusted log-binomial regression analysis for skill attainment between the CORAL and BASELINE cohorts—complete case analysis
| Developmental milestone | CORAL cohort (n=309) Reached milestone % (n) | BASELINE cohort (n=1629) Reached milestone % (n) | Adjusted log-binomial regression models# (n=1793) Relative risk (95% CI) P value* | Regression diagnostics |
| Stand alone | Yes: 65.7 (203/309) | Yes: 66.3 (1080/1629) | 1.00 (0.91 to 1.11) p=0.99 | AIC: 1.87 AUC: 0.61 |
| Side steps | Yes: 89.6 (277/309) | Yes: 86.9 (1416/1629) | 1.03 (0.98 to 1.09) p=0.18 | AIC: 1.99 AUC: 0.59 |
| Crawl | Yes: 97.4 (300/308) | Yes: 91.0 (1482/1629) | 1.06 (1.03 to 1.09) p<0.01* | AIC: 2.00 AUC: 0.61 |
| Stack bricks | Yes: 72.0 (221/307) | Yes: 78.3 (1276/1628) | 0.93 (0.85 to 1.02) p=0.10 | AIC: 1.95 AUC: 0.59 |
| Finger feeds | Yes: 99 (306/309) | Yes: 98.7 (1608/1629) | 1.00 (0.99 to 1.01) p=0.92 | AIC: 2.00 AUC: 0.65 |
| Pincer | Yes: 99.7 (307/308) | Yes: 99.4 (1620/1629) | 1.00 (0.99 to 1.01) p=0.72 | AIC: 2.00 AUC: 0.69 |
| Knows name | Yes: 98.7 (305/309) | Yes: 98.8 (1610/1629) | 1.00 (0.98 to 1.01) p=0.64 | AIC: 2.00 AUC: 0.57 |
| One definite and meaningful word | Yes: 76.6 (232/303) | Yes: 89.3 (1455/1628) | 0.86 (0.80 to 0.92) p<0.01* | AIC: 1.99 AUC: 0.65 |
| Finger points | Yes: 83.8 (258/308) | Yes: 92.8 (1512/1629) | 0.91 (0.86 to 0.96) p<0.01* | AIC: 2.00 AUC: 0.67 |
| Waves bye-bye | Yes: 87.7 (271/309) | Yes: 94.4 (1537/1629) | 0.94 (0.90 to 0.99) p=0.02* | AIC: 2.00 AUC: 0.68 |
*Results highlighted in bold have statistically significant differences between groups.
† Log-binomial regression models for each skill, adjusted for age at assessment in days, gender, gestational age in weeks, birth order (first or other) and maternal educational attainment.
AIC, Akaike Information Criterion; AUC, area under the curve; BASELINE, Babies After SCOPE: Evaluating the Longitudinal Impact using Neurological and Nutritional Impact; CORAL, Impact of Corona Virus Pandemic on Allergic and Autoimmune Dysregulation in Infants Born During Lockdown.