Characteristics of cohort studies reporting postacute health outcomes in children with SARS-CoV-2 infection
| Total N (%) | Controlled n (%) | Uncontrolled n (%) | |
| Total | 21 (100) | 6 (28.6) | 15 (71.4) |
| Region | |||
| Europe | 12 (57.1) | 5 (83.3) | 7 (46.7) |
| Asia* | 6 (28.6) | 0 (0) | 6 (40) |
| North America | 2 (9.5) | 1 (16.7) | 1 (6.7) |
| Oceania | 1 (4.8) | 0 (0) | 1 (6.7) |
| Population | |||
| Hospitalised only | 12 (57.1) | 1 (16.7) | 11 (73.3) |
| Hospitalised and outpatient | 4 (19.0) | 1 (16.7) | 3 (20) |
| General population | 4 (19.0) | 4 (66.7) | 0 (0) |
| Emergency department only | 1 (4.8) | 0 (0) | 1 (6.7) |
| Sample size | |||
| <100 | 12 (57.1) | 1 (16.7) | 11 (73.3) |
| 100–500 | 4 (19.0) | 1 (16.7) | 3 (20.0) |
| 501–1000 | 2 (9.5) | 1 (16.7) | 1 (6.7) |
| >1000 | 3 (14.3) | 3 (50.0) | – |
| Definition of exposure (SARS-CoV-2 infection) | |||
| Using RT-PCR only | 11 (52.4) | 1 (16.7) | 10 (66.7) |
| Using RT-PCR or serology | 5 (23.8) | 2 (33.3) | 3 (20.0) |
| Using RT-PCR, antigen or serology | 2 (9.5) | 1 (16.7) | 1 (6.7) |
| Unclear† | 2 (9.5) | 1 (16.7) | 1 (6.7) |
| Using serology only | 1 (4.8) | 1 (16.7) | 0 (0) |
| Definition of no-exposure (control group) | |||
| No diagnosis or symptoms | – | 3 (50.0) | – |
| Using serology | – | 2 (33.3) | – |
| Using RT-PCR | – | 1 (16.7) | – |
| Study registration | |||
| Mentioned | 2 (9.5) | 2 (33.3) | 0 (0) |
| Not mentioned | 19 (90.5) | 4 (66.7) | 15 (100) |
| Study protocol | |||
| Mentioned | 2 (9.5) | 2 (33.3) | 0 (0) |
| Not mentioned | 19 (90.5) | 4 (66.7) | 15 (100) |
| Ethical approval | |||
| Yes | 19 (90.5) | 6 (100) | 13 (86.7) |
| No full review† | 1 (4.8) | 0 (0) | 1 (6.7) |
| Unclear† | 1 (4.8) | 0 (0) | 1 (6.7) |
*Including Russia.
†Two studies did not provide information on the methods used26 42 As the data analysis was retrospective and no additional data were collected beyond those required for standard medical care, a full ethics review under the terms of the Governance Arrangements of Research Ethics Committees in the UK was not required.
‡One study did not report on ethical approval.34
No., number.