Descriptive summary of blood chemistry parameters by randomised treatment arm
| Parameter | Statistic | Day 0 | Day 2 | Day 7 | |||
| SOC | SOC-F | SOC | SOC-F | SOC | SOC-F | ||
| (n=59) | (n=61) | (n=59) | (n=61) | (n=6) | (n=7) | ||
| Sodium (mmol/L) | Range (min-max) | 126–145 | 125–149 | 126–143 | 126–149 | 136–144.8 | 128–141 |
| Mean (SD) | 135.4 (4.1) | 136.4 (5.3) | 135.7 (3.8) | 136.6 (4.6) | 138.6 (3.3) | 135.7 (4.2) | |
| Median (IQR) | 136 (132–138) | 136 (133–140) | 136 (133.5–138) | 136 (134–140) | 137.9 (136–139) | 136 (134–139) | |
| n (missing) | 59 (0) | 61 (0) | 48 (11) | 54 (7) | 6 (0) | 7 (0) | |
| Creatinine (μmol/L) | Range (min-max) | 32–147 | 35–142 | 39–135 | 33–122 | 40–77 | 40–74 |
| Mean (SD) | 92.3 (28) | 88.5 (24.1) | 73.7 (24.1) | 72.2 (20) | 59.2 (12.7) | 62 (11.4) | |
| Median (IQR) | 96.5 (70–113) | 89 (74–109) | 72 (54.5–87) | 70 (57–83) | 59.5 (53–66) | 65 (57–72) | |
| n (missing) | 58 (1) | 61 (0) | 52 (7) | 55 (6) | 6 (0) | 7 (0) | |
| Potassium (mmol/L) | Range (min-max) | 2.9–6.2 | 2.7–6.2 | 2.8–5.7 | 2.3–4.8 | 2.5–4.9 | 2.9–5.2 |
| Mean (SD) | 4.3 (0.6) | 4.3 (0.7) | 3.9 (0.7) | 3.5 (0.7) | 4.1 (0.9) | 3.9 (0.9) | |
| Median (IQR) | 4.3 (3.9–4.6) | 4.2 (3.8–4.7) | 3.9 (3.4–4.4) | 3.5 (3–4) | 4.3 (3.8–4.9) | 4 (3–4.4) | |
| n (missing) | 59 (0) | 61 (0) | 48 (11) | 55 (6) | 6 (0) | 7 (0) | |
| Alanine transaminase (U/L) | Range (min-max) | 23–238 | 25–244 | 15–475 | 16–152 | 44–83 | 23–64 |
| Mean (SD) | 90.6 (58.4) | 81.8 (46.5) | 73.1 (78.3) | 59.9 (32.5) | 64.8 (18.3) | 44.7 (14.2) | |
| Median (IQR) | 74 (54–99) | 68 (45–115) | 51 (38.5–70) | 56.5 (35–77) | 66 (49.5–80) | 46.5 (35–53) | |
| n (missing) | 37 (22) | 46 (15) | 48 (11) | 50 (11) | 4 (2) | 6 (1) | |
n, number; SOC, standard of care; SOC-F, standard of care plus fosfomycin.