Table 2

Analytical results of the genetic (mtDNA), functional (CIV) and biogenic (CS) assays from infants with congenital CMV infection and controls

CTLG0 (0–2 m)G3 (2–4 m)G6 (5–8 m)G12 (9–16 m)
UTVALUTVALUTVALUTVAL
mtDNA
(mtDNA/nDNA)
(60–144)91.83
95% CI 78 to 105
91.33
95% CI 78 to 104
83.33
95% CI 72 to 94
97.82
95% CI 87 to 108
82.50
95% CI 63 to 101
88.38
95% CI 81 to 104
88.67
95% CI 72 to 105
80.07
95% CI 72 to 87
CIV
(nmoles/min × mg protein)
(11–59)41.5
95% CI 15 to 67
40.75
95% CI 26 to 55
38.33
95% CI 19 to 57
37.18
95% CI 23 to 50
28.50
95% CI 17 to 39
50.13
95% CI 20 to 80
38.67
95% CI 26 to 51
46.60
95% CI 32 to 60
CS (nmoles/min × mg protein)(60–162)113.7
95% CI 94 to 132
106.3
95% CI 96 to 116
104
95% CI 90 to 117
109.2
95% CI 89 to 129
101.2
95% CI 92 to 110
115.9
95% CI 93 to 137
104.4
95% CI 94 to 114
103.8
95% CI 96 to 111
mtDNA/CS(0.8–2.8)1.49
95% CI 1.1 to 1.8
1.69
95% CI 1.4 to 1.9
1.5
95% CI 1.2 to 1.7
1.56
95% CI 1.3 to 1.7
1.43
95% CI 1.1 to 1.7
1.50
95% CI 1.0 to 1.9
1.51
95% CI 1.3 to 1.7
1.40
95% CI 1.2 to 1.6
CIV/CS(13–48)21.17
95% CI 10 to 31
20.50
95% CI 16 to 24
25.22
95% CI 13 to 36
24.40
95% CI 16 to 32
20.80
95% CI 12 to 29
24.63
95% CI 16 to 33
26.11
95% CI 20 to 31
27.27
95% CI 23 to 31
  • P>0.05 in all cases.

  • mtDNA. mitochondrial DNA; CIV, complex IV of the mitochondrial respiratory chain; CS, citrate synthase; CTL, control; G, group; UT, untreated; VAL, valganciclovir.