Table 1

Demographics and clinical manifestations of the quarantine and control cohorts of patients with PFAPA

VariableQuarantine group
(n=8)
Control group
(n=9)
P value*
Age in years, median (IQR)2.82 (1.74–4.62)3.11 (3.06–3.64)0.88
Male sex, n (%)3 (37.5%)2 (22.2%)0.62
Family history of recurrence of: fevers, aphthous ulcers and/or tonsillitis in first-degree relative, n (%)4 (50%)6 (66.6%)0.64
Presence of aphthous ulcers, n (%)1 (12.5%)1 (11.1%)1.00
Presence of pharyngitis, n (%)3 (37.5%)2 (22.2%)0.62
Presence of exudative pharyngitis, n (%)3 (37.5%)4 (44.4%)1.00
Presence of lymphadenopathy, n (%)5 (62.5%)5 (55.6%)1.00
History of sick contacts and/or child care centre attendance, n (%) 0 (0%)* 8 (88.9%)* 0.0004*
History of travel in past year, n (%) 1 (12.5%)* 5 (55.6%)* 0.02*
Additional siblings at home, n (%)6 (75.0%)6 (66.7%)1.00
Household (family) members getting sick when subject is febrile? n (%)0 (0%)2 (22.2%)0.32
  • *As determined by Mann-Whitney test for continuous variables and Fisher’s exact test for categorical variables, with statistical significance at p<0.05.

  • PFAPA, periodic fever accompanied by aphthous stomatitis, pharyngitis and/or cervical adenitis.