Univariable odds of developing acute kidney injury during paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2, as estimated by logistic regression modelling
| Variable | OR (95% CI) | Wald z statistic | P value |
| Demographics | |||
| Age (per 1-year increase) | 0.99 (0.98 to 1) | −1.64 | 0.09 |
| Male | 0.71 (0.31 to 1.63) | −0.78 | 0.43 |
| Ethnicity | 1.45 | 0.15 | |
| White | 1 | ||
| Non-white | 2.6 (0.79 to 11.9) | ||
| BMI centile (per 5-unit increase) | 1.05 (0.98 to 1.13) | 1.27 | 0.2 |
| Symptoms on admission | |||
| Diarrhoea | 1.91 (0.82 to 4.72) | 1.47 | 0.14 |
| Vomiting | 1.24 (0.54 to 2.9) | 0.51 | 0.61 |
| Respiratory distress | 2.41 (1.01 to 5.8) | 1.98 | 0.05 |
| Admission blood parameters | |||
| Triglycerides (per 1 mmol/L increase) | 1.27 (1.05 to 1.6) | 2.36 | 0.02 |
| Ferritin (per 100 µg/L increase) | 0.99 (0.99 to 1.01) | −0.05 | 0.96 |
| CRP (per 10 mg/L increase) | 1.06 (1.02 to 1.12) | 2.68 | 0.008 |
| D-dimer (per 1000 ng/mL increase) | 1.07 (1.03 to 1.14) | 2.94 | 0.003 |
| Troponin (per 10 ng/L increase) | 1 (1 to 1.01) | 1.94 | 0.05 |
| NT-proBNP (per 1000 pg/mL increase) | 1.03 (1.004 to 1.07) | 2.2 | 0.02 |
| Intensive care | |||
| Mechanical ventilation | 3.8 (1.46 to 10.4) | 2.71 | 0.006 |
| Inotropic support | 15.4 (3.02 to 28.1) | 2.63 | 0.009 |
| Duration of PICU stay (per 1 day) | 1.1 (0.93 to 1.32) | 1.17 | 0.23 |
| Duration of inotropic support (per 1 day) | 1.2 (0.97 to 1.54) | 1.62 | 0.1 |
| Medications | |||
| Nephrotoxic medications (per 1-unit increase) | 1.26 (0.76 to 2.05) | 0.91 | 0.36 |
Data are odds ratio (95% CI).
BMI, body mass index; CRP, C reactive protein; NT-proBNP, N-terminal pro B-type natriuretic peptide; PICU, paediatric intensive care unit.