Data taken from clinical and electronic records of those recruited to the MaCROS study
Patient no | Age | Probiotic/ placebo | Diagnosis | Inpatient (routine chemotherapy) | Was routine admission for chemotherapy extended? | Febrile | Febrile neutropenic? | Positive blood culture? | Organism |
1* | 12 years | Probiotic | Ewing’s sarcoma | Yes | No | No | No | N/A | |
2 | 13 years | Placebo | Osteosarcoma | Yes | Yes | Yes | No | No | |
3 | 7 years | Probiotic | Undifferentiated sarcoma | Yes | No | No | No | NA | |
4 | 12 years | Placebo | HR NBL- HD chemo and stem cell rescue | Yes | NA† | Yes | Yes | No | |
5 | 1 year, 7 months | Probiotic | HR NBL | Yes | No | No | No | Yes |
Streptococcus mitis/oralis, Streptococcus vestibularis, Streptococcus parasangui |
6 | 1 year, 7 months | Probiotic | HR NBL HD chemo and stem cell rescue | Yes | NA† | Yes | No | Yes | Gram negative bacilli |
7 | 14 years | Placebo | AML | Yes | NA† | Yes | Yes | No | |
8 | 3 years | Placebo | NHL | Yes | Yes | Yes | Yes | No | |
9* | 15 years | Placebo | Metastatic-relapsed osteosarcoma | No | No | No | No | NA | |
10 | 8 years | Placebo | Osteosarcoma | Yes | Yes | Yes | No | No |
*Withdrawn.
†Inpatient until count recovered.
AML, acute myeloid leukaemia; HD, high dose; HR NBL, high-risk neuroblastoma; NHL, non-Hodgkins lymphoma.