Clinical signs and symptoms at presentation
| MIS-C+ (n=50) | MIS-C- (n=68) | P value | |
| n (%) | n (%) | ||
| Kawasaki disease criteria | |||
| Rash | 23 (46) | 31 (46) | 1 |
| Oral mucosa changes | 12 (24) | 5 (7) | 0.016 |
| Conjunctivitis | 29 (58) | 10 (15) | <0.001 |
| Hand/Foot redness or swelling | 5 (10) | 9 (13) | 0.77 |
| Lymphadenopathy ≥1.5 cm | 1 (2) | 7 (10) | 0.14 |
| Symptoms | |||
| Abdominal pain | 29 (58) | 10 (15) | <0.001 |
| Vomiting | 21 (42) | 21 (31) | 0.25 |
| Diarrhoea | 20 (40) | 21 (31) | 0.33 |
| Cough | 9 (18) | 5 (7) | 0.09 |
| Shortness of breath | 2 (4) | 2 (3) | 1 |
| Fatigue | 14 (28) | 7 (10) | 0.016 |
| Headache | 14 (28) | 9 (13) | 0.06 |
| Altered mental status | 1 (2) | 4 (6) | 0.39 |
| Days of fever at presentation—median (IQR) | 5 (3–6) | 5 (3–7) | 0.74 |
| Vital signs within 24 hours of presentation | |||
| Fever | 36 (72) | 53 (78) | 0.52 |
| Tachycardia | 41 (82) | 53 (78) | 0.65 |
| Tachypnoea | 37 (74) | 24 (35) | <0.001 |
| Hypotension (n=117)* | 19 (39) | 4 (6) | <0.001 |
| Hypoxaemia (O2<95%) | 13 (26) | 5 (7) | 0.008 |
*Not available for patient requiring extracorporeal membrane oxygenation.
MIS-C, multisystem inflammatory syndrome in children.