Table 1

Study characteristics

Author, year
(reference)
Diagnostic criteriaSettingStudy designInterventionSample at baseline (n)Sample at follow-up n (% baseline)Mean age (SD) (range)Sex n/total at baseline
(% female)
Follow-up (SD)(range)
Chalder et al, 200214 CDC/OxfordTertiaryObservationalFamily-focused CBT: up to 15 1-hour sessions2318 (78%)NR
(11–18)
20/23 (87%)6 months
Chalder et al, 201023 CDC/OxfordTertiaryRCTFamily-focused CBT (13 fortnightly 1-hour sessions) vs pyschoeducation63NR
NR
59 (94%)
NR
(13.0–17.0)
43/63 (68%)3 months
6 months
12 months
Lloyd et al, 2012
(follow-up of Chalder et al, 2010)21
CDC/OxfordTertiaryRCTFamily-focused CBT (13 fortnightly 1-hour sessions) vs psychoeducation6344 (70%)15 (1.7)
(11–18)
32/63 (51%)24 months
Crawley et al, 20113 NICESchoolObservationalSpecialist medical care offered to those diagnosed with CFS/ME23NR
19 (83%)
14.6 (1.5)17/23 (74%)1.5 months
6 months
Katz et al, 200918 CDCSecondary/tertiaryObservationalNo intervention3936 (92%)
33 (85%)
NR35/39 (90%)6 months
18 months
Lim and Lubitzl, 200224 CDCTertiaryObservationalFour-week intensive multidisciplinary inpatient programme5742 (74%)15
(10–19)
50/57 (88%)3.5 years (3 months to 5 years)
Nijhof et al, 201215 CDCTertiaryRCTInternet-based CBT vs usual care135131 (97%)
127 (94%)
15.9 (1.3)111/135 (82%)6 months
12 months
Nijhof et al, 2013
(follow-up of Nijhof et al, 2012)22
CDCTertiaryLong-term follow-up of RCTInternet-based CBT vs usual care (with post-RCT crossover)127112 (88%)15.8 (1.4)105/127 (83%)2.7 years (0.5)(1.7–3.8 years)
Rowe, 199919 CDCTertiaryRCTGammaglobulin vs placebo8986 (97%)NRNR (NR)56 months (25 months)(15–112 months)
Stulemeijer et al, 200520 CDCTertiaryRCTCBT (10 sessions) vs waiting list6962 (90%)15.7 (1.3)62/69 (90%)5 months
Van Geelen et al, 201017 CDCTertiaryObservationalRegular care6054 (90%)16.0 (1.5)NR (79.6%)2.2 years (1.6)
Viner et al, 200416 Modified CDCTertiaryObservationalRehabilitative programme vs supportive care7856 (72%)
32 (41%)
24 (31%)
17 (22%)
14.2
(9–17)
49/78 (63%)6 months
12 months
18 months
24 months
  • CBT, cognitive-behavioural therapy; NR, not reported; RCT, randomised controlled trial.