Clinical characteristics and 2-year outcomes of infants with HIE who underwent therapeutic hypothermia at CMU Hospital
| Patients characteristics | N=23 |
| Male, n (%) | 17 (73.9) |
| Born at the CMU Hospital, n (%) | 7 (30.4) |
| Gestational age (weeks)* | 37.7 (1.9) |
| Birth weight (g)† | 2890 (2,660-3,310) |
| Complication during labour, n (%) | |
| Abnormal foetal heart rate monitoring, cat. II–III | 9 (39.1) |
| Shoulder dystocia | 3 (13.0) |
| Prolapsed cord | 2 (8.7) |
| Types of labour, n (%) | |
| Caesarean section | 9 (39.1) |
| Vacuum/forceps extraction | 7 (30.4) |
| Breech assistance | 3 (13.0) |
| Apgar at 10 min† | 4 (0–6) |
| First arterial blood gas/venous blood gas/capillary blood gas after birth† (n=17) | |
| pH | 7.1 (5.8–7.3) |
| BD (mmol/L) | 16.2 (6.9) |
| Severity of HIE, n (%) | |
| Moderate | 19 (82.6) |
| Severe | 4 (17.4) |
| Clinical seizure, n (%) | 16 (84.2) |
| Admission temperature (°C)* | 35.9 (1) |
| Incomplete TH criteria, n (%) | 5 (21.7) |
| Age >6 hours | 5 (21.7) |
| GA <35 weeks | 1 (4.3) |
| Age at targeted temperature (33–34°C) was reached (hour)* | 5.8 (1.8) |
| Complete 72 hours of TH, n (%) | 19 (82.6) |
| Death during TH, n (%) | 3 (13.0) |
| Death during admission, n (%) | 4 (17.4) |
| Duration of neonatal intensive care unit stay (days)† | 30 (13–40) |
| Outcomes at 2 years of follow-up | N=11 |
| Age at follow-up (months)† | 28 (24–65) |
| GMFCS 3–5, n (%) | 3 (27.3) |
| GMFCS 2, n (%) | 1 (9.1) |
| Blindness, n (%) | 3 (27.3) |
| Severe hearing loss, n (%) | 0 (0.0) |
| BSID-III* | |
| Cognitive composite score | 72.2 (16.2) |
| Language composite score | 63.8 (21.1) |
| Motor composite score | 72.4 (24.8) |
| Retaining feeding tube, n (%) | 2 (18.2) |
| Requiring oxygen support, n (%) | 0 (0.0) |
| Receiving neurological medication, n (%) | 4 (36.4) |
| Alive without neurological impairment, n (%) | 3 (27.3) |
*Data presented as mean (SD).
†Data presented as median (min–max).
Bayley-III, Bayley Scales of Infant and Toddler Development, Third Edition; CMU, Chiang Mai University; GMFCS, Gross Motor Function Classification System; HIE, hypoxic–ischaemic encephalopathy; TH, therapeutic hypothermia.