Table 2

Primary adjunctive corticosteroids vs historical controls

Primary adjunctive corticosteroids n=48Historical controls n=162P value
Age at fever onset (years)1.9 (0.9, 3.3)2.9 (0.1, 5.9)0.020
Age <6 months7 (15%)16 (10%)0.43
Male sex34 (71%)117 (72%)0.86
Asian ethnicity13 (27%)31 (19%)0.23
Complete KD criteria36 (74%)112 (69%)0.48
Days of fever prior to first IVIG0.74
 <722 (46%)80 (49%)
 7–1026 (54%)82 (51%)
Baseline laboratory data
WBC15.4 (11.2 to 18.6)15.9 (12.3 to 20.5)0.64
Haematocrit32.3 (29.9 to 34.5)31.0 (28.9 to 33.4)0.066
Platelet count385 (308 to 523)388 (296 to 538)0.78
CRP8.1 (5.2 to 12.7)9.1 (5.1 to 15.2)0.42
Sodium135 (133 to 138)134 (132 to 137)0.09
Albumin3.4 (3.0 to 3.7)3.1 (2.8, 3.5)0.024
AST25 (21 to 40)37 (25 to 55)0.002
Baseline coronary data
z-Score of largest CAA at diagnosis3.6 (2.9 to 5.2)3.3 (2.8 to 4.2)0.13
z-Score of largest CAA at diagnosis0.016
 2.5 to 4.9935 (73%)143 (88%)
 5.0 to 9.998 (17%)15 (9%)
 z-score ≥105 (10%)4 (3%)
Bilateral CAA18 (38%)50 (31%)0.39
Treatment
2nd IVIG30 (63%)67 (41%)0.013
Secondary adjunctive therapy6 (13%)19 (12%)1.0
  • Values are number (%) or median (IQR).

  • AST, aspartate aminotransferase; CAA, coronary artery aneurysm; CRP, C reactive protein; IVIG, intravenous immunoglobulin; KD, Kawasaki disease; WBC, white blood cell.