Table 2

Summary of clinical characteristics and interventions for children with a PCR-positive diagnosis of SARS-CoV-2 infection. Children who presented with a paediatric inflammatory multisystem syndrome were excluded from this description

Blood markersMedian measurement (range)
Maximum leucocyte count (×109/L)15.4 (6.01–24.75)
Lymphocyte count (×109/L)1.15 (0–2.94)
Maximum ferritin (μg/L)898 (264–1991)
Maximum LDH (units/L)1594 (802–4264)
Maximum D-dimer (μg/L)1655 (162–6742)
Maximum CRP (mg/L)158 (27–449)
Maximum temperature during ICU admission (oC), median (IQR)39.5 (38.4–40)
OSI, median (IQR)
 Day 15.2 (4.1–7.0)
 Day 26.6 (4.3–7.6)
 Day 35.1 (3.6–6.74)
ICU therapies, n (%)
 Invasive mechanical ventilation9 (81)
 Prone position4 (36)
 Neuromuscular blockade5 (46)
 Inhaled pulmonary vasodilators*4 (36)
 High-frequency oscillation ventilation2 (11)
 Renal replacement therapy0
 ECMO0
 Vasoactive drugs5 (46)
Anticoagulation, n (%)
 Therapeutic dose3 (27)
 Prophylactic dose5 (46)
Antiviral medication, n (%)
 Remdemisvir5 (46)
Outcomes
 Survival to ICU discharge11
 Survival to hospital discharge11
 Median length of ICU stay (IQR), days10 (3.2–13.0)
  • Entire ranges presented for maximum or minimum blood parameters rather than IQRs.

  • *Inhaled nitric oxide or inhaled prostacyclin.

  • †Leucocyte and lymphocyte counts include results from two children with oncological diagnoses.

  • ‡OSI data exclude data from two children not ventilated and one child prior to correction of cyanotic congenital heart disease.

  • CRP, C reactive protein; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; LDH, lactate dehydrogenase; OSI, oxygen saturation index; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.