Summary of clinical characteristics and interventions for children with a PCR-positive diagnosis of SARS-CoV-2 infection. Children who presented with a paediatric inflammatory multisystem syndrome were excluded from this description
| Blood markers | Median measurement (range) |
| Maximum leucocyte count (×109/L) | 15.4 (6.01–24.75) |
| Lymphocyte count (×109/L) | 1.15 (0–2.94) |
| Maximum ferritin (μg/L) | 898 (264–1991) |
| Maximum LDH (units/L) | 1594 (802–4264) |
| Maximum D-dimer (μg/L) | 1655 (162–6742) |
| Maximum CRP (mg/L) | 158 (27–449) |
| Maximum temperature during ICU admission (oC), median (IQR) | 39.5 (38.4–40) |
| OSI, median (IQR) | |
| Day 1 | 5.2 (4.1–7.0) |
| Day 2 | 6.6 (4.3–7.6) |
| Day 3 | 5.1 (3.6–6.74) |
| ICU therapies, n (%) | |
| Invasive mechanical ventilation | 9 (81) |
| Prone position | 4 (36) |
| Neuromuscular blockade | 5 (46) |
| Inhaled pulmonary vasodilators* | 4 (36) |
| High-frequency oscillation ventilation | 2 (11) |
| Renal replacement therapy | 0 |
| ECMO | 0 |
| Vasoactive drugs | 5 (46) |
| Anticoagulation, n (%) | |
| Therapeutic dose | 3 (27) |
| Prophylactic dose | 5 (46) |
| Antiviral medication, n (%) | |
| Remdemisvir | 5 (46) |
| Outcomes | |
| Survival to ICU discharge | 11 |
| Survival to hospital discharge | 11 |
| Median length of ICU stay (IQR), days | 10 (3.2–13.0) |
Entire ranges presented for maximum or minimum blood parameters rather than IQRs.
*Inhaled nitric oxide or inhaled prostacyclin.
†Leucocyte and lymphocyte counts include results from two children with oncological diagnoses.
‡OSI data exclude data from two children not ventilated and one child prior to correction of cyanotic congenital heart disease.
CRP, C reactive protein; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; LDH, lactate dehydrogenase; OSI, oxygen saturation index; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.