Table 2

Review of literature on prior attempts on splitting of ventilation for multiple patient use

Author, yearSubjectsStrategyConclusions
Clark et al, 202013Simulation modelTwo test lungs of different compliance tested with single ventilatorDemonstrated capacity to simultaneously ventilate two test lungs of different compliance
Raredon et al, 202014Simulation modelPressure-regulated ventilator splitting Yale University protocol—used customised circuits with inspiratory pressure gated valves with ins that can support two test lungs with individualised peak-inspiratory and end-expiratory pressuresTailoring of ventilator pressures for each patient, and the ability to titrate those pressures over time, may provide a more useful means of stretching ventilator resource.
Tornstad and Olsen, 202015Simulation modelTechnical assessment using test lungs of different compliance and resistanceDiscrepancies in delivered tidal volume in paired lungs, not able to identify reliable settings
Vries et al, 202016DescriptiveTechnical descriptionDescribed methods for set up and monitoring
Branson et al, 20129Simulation modelFour test lungs with different combination of compliance and resistanceEvenly distributed ventilation in equal lungs but large differences in ventilation in lungs with different compliance
Smith and Brown, 200917Two healthy human volunteersSingle ventilator used in two healthy human volunteersAccepted CO2 levels after 10 min of ventilation
Paladino et al, 200818Four adult human-sized sheepSingle ventilator with modified circuits ventilated for 12 hoursSufficient ventilation, oxygenation and haemodynamic stability throughout experiment
Neyman and Irvin, 20068Simulation modelFour equal test lungs ventilated for 6 hoursEvenly distributed ventilation among all test lungs