Case ID | Age (years) | Preintervention T2*CMR value (ms)* | Cause of death | Time to death† (days) | Preintervention compliance with chelation | Postintervention compliance with chelation | AE severity level | Presence of cardiac dysfunction on TTE at baseline | Presence of arrhythmia on holter at baseline‡ | Presence of pulmonary hypertension at baseline |
1 | 25 | 4.3 | Heart failure | 730 | Partial | Optimal compliance | No AE | Absent | Absent | Present |
2 | 13 | 12.3 | Heart failure | 514 | Non-compliant | Optimal compliance | No AE | Absent | Absent | Absent |
3 | 23 | 4.5 | Heart failure | 715 | Non-compliant | Optimal compliance | No AE | Absent | Present | Absent |
4 | 23 | 2.6 | Arrhythmia (ventricular tachycardia) | 542 | Partial | Optimal compliance | 1 | Present | Present | Absent |
5 | 18 | 15.3 | Intracranial bleed secondary to pancytopenia | 472 | Partial | Optimal compliance | No AE | Absent | Absent | Absent |
6 | 24 | 6.3 | Myxedema (cardiomyopathy and anasarca), infective endocarditis (thromboembolism), sepsis and heart failure | 110 | Non-compliant | Optimal compliance | 1 | Absent | Present | Absent |
7 | 11.5 | 4.7 | Intracranial bleed secondary to pancytopenia | 190 | Partial | Optimal compliance | 2 | Absent | Absent | Absent |
8 | 19 | 2.6 | Intracardiac thrombus and pulmonary embolism | 97 | Non-compliant | Optimal compliance | 2 | Present | Present | Present |
9 | 26 | 9 | Hepatitis C, severe backache, dyspnoea, chronic liver disease, ascites, congestive cardiac failure and massive spleen with varices | 257 | Partial compliance | Optimal compliance | No AE | Present | Absent | Absent |
10 | 18 | 3 | Febrile neutropenia, pain, swelling and bluish discoloration over knee joint, severe abdominal pain and dyspnoea | 75 | Non-compliant | Optimal compliance | 3 | Absent | Present | Absent |
11 | 10 | 33.2 | Intracranial bleed and sepsis secondary to pancytopenia | 363 | Non-compliant | Partial compliance | No AE | Absent | Absent | Absent |
12 | 16 | 11.5 | Intracranial bleed secondary to pancytopenia | 957 | Non-compliant | Partial compliance | 3 | Absent | Absent | Absent |
13 | 24 | 5.9 | Intracranial bleed secondary to pancytopenia | 686 | Partial | Optimal compliance | No AE | Absent | Present | Absent |
*Postintervention T2*CMR was not performed.
†This is defined as the time to death from the beginning of the intervention. All patients died during the postintervention phase.
‡Described as sustained and non-sustained atrial and ventricular tachycardia.
AE, adverse events; T2*CMR, cardiac T2* magnetic resonance imaging; TTE, transthoracic echocardiography.