Table 7

Relationship between total fatigue and HRQoL for children with chronic diseases (n=481)

Unadjusted modelAdjusted model *
Mean difference95% CIMean difference95% CI
Total HRQoL0.69 0.64 to 0.73 0.70 0.65 to 0.75
Physical functioning0.79 0.66 to 0.91 0.80 0.68 to 0.92
Emotional functioning0.65 0.57 to 0.73 0.70 0.62 to 0.78
Social functioning0.53 0.46 to 0.60 0.56 0.49 to 0.63
School functioning0.76 0.69 to 0.83 0.75 0.68 to 0.82

  • PedsQL GCS is scored on a scale from 0 to 100, with lower scores indicating reduced HRQoL. Positive mean differences indicate a higher HRQoL score on the PedsQL GCS, indicating higher HRQoL. Specifically, for each 1-point reduction in the PedsQL MFS score (indicating more fatigue), the same child’s score for HRQoL was on average 0.70 points lower.

  • *The adjusted model was corrected for age, sex and reporting method (child or proxy).

  • Significant differences in bold.

  • HRQoL, health-related quality of life; PedsQL GCS, PedsQL generic core scales.