Severity criteria for neonatal convulsions, as an example of the specific severity criteria per AE given in INC NAESS (online supplementary appendix 6)
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
| Mild | Moderate | Severe | Life threatening | Death |
|
Neonatal convulsion
Definition C154952 │ 10028932: Sudden, involuntary, rapid, rhythmic or stereotyped skeletal muscular contractions in a newborn. | ||||
| Single, self-limited suspected seizure, no treatment. | Suspected seizures controlled with one anti-seizure drug (no recurrence within 3 days after treatment). | Suspected seizures uncontrolled with one antiseizure drug (recurrence within 3 days after treatment or requiring two or more antiseizure drugs). | Suspected seizures with life-threatening consequences (eg, need for ventilation); suspected status epilepticus* despite multiple anti-seizure drugs. | Death related to suspected seizures. |
*>30 min duration of convulsions within any 60 min period.
AE, adverse event; INC, International Neonatal Consortium; NAESS, neonatal AE severity scale.