Patients with FWS (n=135) | Controls (n=50) | P value | |
Demographics | |||
Median age, months (IQR) | 2.4 (1.3–9.8) | 19.0 (13.4–25.9) | <0.001 |
Male sex, n (%) | 80 (59.3) | 30 (60.0) | 0.927 |
Season of enrolment | |||
Spring | 27 (20.0) | 6 (12.0) | <0.001 |
Summer | 38 (28.1) | 0 | |
Autumn | 36 (26.7) | 40 (80.0) | |
Winter | 34 (25.2) | 4 (8.0) | |
Virology results | |||
Any viraemia, n (%) | 47 (34.8) | 3 (6.0) | <0.001 |
Human enterovirus, n (%) | 19 (14.1) | 0 | 0.002 |
Median CT value (IQR) | 28.7 (27.6–31.9) | ||
Median copies/mL (IQR) | 9430 (1210–25 900) | ||
Human parechovirus, n (%) | 8 (5.9) | 2 (4.0) | 0.462 |
Median CT value (IQR) | 31.6 (26.8–34.7) | – (36.8–37.5)† | |
Human herpesvirus type 6, n (%) | 15 (11.1) | 1 (2.0) | 0.038 |
Median CT value (IQR) | 32.6 (30.3–33.5) | 39.7† | |
Median copies/mL (IQR)* | 61 900 (3438–90 200) | <250 (–)† | |
Adenovirus, n (%) | 7 (5.2) | 0 | 0.106 |
Median CT value (IQR) | 32.1 (31.0–35.8) | ||
Median copies/mL (IQR)* | 14 050 (5190–25 325) |
*Leftover volume was insufficient to perform quantitative PCR in 3 patients for adenovirus and in 7 patients for human herpesvirus type 6.
†Median or IQR was not calculated given the number of positive cases.
CT, cycle threshold; FWS, fever without source.