Table 1

Overview of the Fluids in Shock (FiSh) and Fever feasibility study designs

FiShFever study
AimsTo establish the feasibility of conducting a randomised controlled trial comparing restrictive fluid bolus therapy (10 mL/kg) with the current UK recommended practice (20 mL/kg).To establish the feasibility of conducting a definitive trial comparing temperature thresholds at which staff deliver antipyretic intervention in critically ill children with fever due to infection (intervention treat at ≥39.5°C, standard care treat at >37.5°C).
Feasibility study elements(1) Qualitative study exploring parent views. (2) Nine-month pilot trial with integrated parent and staff perspectives study.(1) Qualitative study exploring parent and clinician views. (2) Observational study of the epidemiology of fever in children with infection in paediatric intensive care unit. (3) Four-month pilot trial with integrated parent and staff perspectives study.
Pilot trial participantsChildren (age >37 weeks (corrected gestational age) and <16 years) admitted to an emergency department with clinical suspicion of infection and signs of shock after receipt of 20 mL/kg of bolus fluid.Children (age >29 days and <16 years) admitted to intensive care with a fever (≥37.5°C) in the first 48 hours and suspected infection who require mechanical ventilation.