Multivariate analysis of demographic and clinical characteristics associated with treatment abandonment
| Feature | Category | Patients not abandoning treatment n (%) | Patients abandoning treatment n (%) | OR (95% CI) | P value |
| Age (years) | 1–9 | 2058 (97.9) | 44 (2.1) | ||
| ≥10 | 267 (95.4) | 13 (4.6) | 1.07 (0.51 to 2.16) | 0.8539 | |
| <1 | 24 (96) | 1 (4.0) | 1.06 (0.06 to 5.85) | 0.9561 | |
| Risk group* | Low | 1585 (98.5) | 24 (1.5) | ||
| Standard/high | 764 (95.7) | 34 (4.3) | 2.62 (1.43 to 4.77) | 0.0016 | |
| MRD, day 19 | Negative | 1085 (98.3) | 19 (1.7) | ||
| Positive | 1264 (97.0) | 39 (3.0) | 1.09 (0.58 to 2.10) | 0.7825 | |
| MRD, day 46† | Negative | 2001 (98.3) | 35 (1.7) | ||
| Positive | 348 (93.8) | 23 (6.2) | 3.57 (1.90 to 6.74) | 0.0007 | |
| Region | High income | 1336 (98.1) | 26 (1.9) | ||
| Middle income | 765 (97.9) | 16 (2.1) | 1.11 (0.58 to 2.08) | 0.7461 | |
| Low income | 248 (93.9) | 16 (6.1) | 3.70 (1.89 to 7.05) | 0.0008 |
*Initial risk determined at diagnosis.
†Patients without day 46 MRD data were excluded.
MRD, minimal residual disease.