Table 1

Studies reporting resource use and/or economic costs associated with the initial hospitalisation (full methodological characteristics presented in online supplementary appendix 3)

StudyDate of birth of study populationLocationType of studySample sizeGestational age(s) (weeks)Birth weight (g)
Allen et al 18 2012–2015USACase series23 weeks: 1223–25<2500
24 weeks: 17
25 weeks: 22
Almond et al 19 1983–2002USARetrospective analysis of national birth cohort>200 000 newborns of 3 ounces around the 1500 g threshold in the nationwide data; approximately 30 000 births in the same interval for the five-state sample.NA3 ounces (85 g) bandwidth from 1500 g threshold
State inpatient research database analysis
1991–20065 US states (Arizona, California, Maryland, New Jersey and New York)
Aly et al 20 2007–2008USARetrospective analysis of national birth cohortAll: 81 91333–34NA
33–34 weeks: 24 08635–36
35–36 weeks: 57 827
Barradas et al 21 2009USARetrospective analysis of national birth cohort4 167 000 (9.1% were preterm or low birth weight)<37<2500
Bird et al 23 2001–2005USA (Arkansas)Retrospective analysis of Medicaid claims database34–36 weeks: 518834–36NA
37–42 weeks: 15 30337–42
Bulut et al 24 2006–2008Turkey (Istanbul)Retrospective chart analysis34–36 weeks: 674234–36NA
≥37 weeks: 30 055≥37
Cavallo et al 25 2006ItalyProspective cohort study≤30 weeks and/or ≤1500 g: 150≤30≤1500
37–42 weeks: 14537–42
Cömert et al 26 2006–2007Turkey (Istanbul)Retrospective chart analysis28–32 weeks: 9628–32NA
33–37 weeks: 11533–37
Hall and Greenberg29 2012USA (Hamilton County, Ohio)Retrospective chart analysis10 976 births of which 1444 were preterm23–27NA
28–31
32–36
Hinchliffe et al 31 2006–2010UK (East Midlands and Yorkshire)Population-based audit of neonatal care24 weeks: 29624–28NA
25 weeks: 384
26 weeks: 551
27 weeks: 663
28 weeks: 829
Khan et al 36 2009–2010UK (East Midlands)Prospective cohort study32–33 weeks: 16232–33NA
34–36 weeks: 98434–36
32–36 weeks: 114632–36
≥37 weeks: 1258≥37
Khashu et al 37 1999–2002Canada (British Columbia)Retrospective analysis of regional birth cohort33–36 weeks: 638133–36NA
37–40 weeks: 88 86737–40
Korvenranta et al 38 2000–2003FinlandRetrospective national register study22–23 weeks: 17<32<1501
24–25 weeks: 135
26–27 weeks: 234
28–29 weeks: 391
30–31 weeks: 771
>31 weeks: 248
Korvenranta et al 40 2000–2003FinlandRetrospective national register studyPreterm survivors:<32<1501
23 weeks: 1737–41
24–25 weeks: 135
26–27 weeks: 231
28–29 weeks: 385
30–31 weeks: 756
Preterm non-survivors: 278
Term: 200 609
Leone et al 42 2006–2007SwitzerlandRetrospective chart analysis34–36 weeks: 53034–36NA
39–40 weeks: 168639–40
Lim et al 43 2005–2006CanadaRetrospective national register studySingletons:<28NA
<28 weeks: 76228–31
28–31 weeks: 109932–33
32–33 weeks: 142834–36
34–36 weeks: 9716≥37
≥37 weeks: 189 750
Multiples:
<28 weeks: 264
28–31 weeks: 418
32–33 weeks: 571
34–36 weeks: 2370
≥37 weeks: 2742
Lo et al 44 2000–2008USARetrospective chart analysisSingleton deliveries: 240 17924–42NA
Mangham et al 46 2006England and WalesDecision-analytic model populated with data from administrative population-based databases≤27 weeks: 3185AllNA
28–31 weeks: 5575
32–33 weeks: 6410
34–36 weeks: 32 812
≥37 weeks: 621 618
McLaurin et al 47 2004USARetrospective analysis of insurance database33–36 weeks: 168333–36NA
≥37 weeks: 33 745≥37
Meyers and Meyers48 2008USARetrospective analysis of national birth cohortNot specifiedAllAll
Mistry et al 49 2001–2002UK (Basildon, Colchester and Southend in Essex and Gillingham in Kent)Prospective cohort studyThree level 2 neonatal units: 192NA≤1800
One level 3 neonatal unit: 199
Nordermoen and Bratlid51 1997–2007NorwayRetrospective analysis of two birth cohortsNot specified<28 weeks 
≥28 weeks
<1500 g
Seaton et al 53 2011–2014EnglandRetrospective analysis of electronic health records2011: 536824–31NA
2012: 5343
2013: 5228
2014: 5099
Stephens et al 54 2001–2011Australia (New South Wales)Retrospective analysis of regional birth cohort24–27 weeks: 365924–27NA
28–31 weeks: 723528–31
32–33 weeks: 900732–33
39–40 weeks: 539 63139–40
Thanh et al 56 2004–2010Canada (Alberta)Retrospective analysis of regional birth cohort<2500 g: 16 209NA<2500 g
≥2500 g: 189 586≥2500 g
van Baaren et al 57 2006–2012The NetherlandsRetrospective analysis of one prospective cohort study and three randomised controlled trials455224–28NA
1090 singletons28–32
3462 multiples32–36
≥37
Xu et al 59 2003USA (Michigan)Retrospective analysis of regional birth cohort<37 weeks: 9780≥20NA
≥37 weeks: 101 484
  • NA, not applicable.