Table 3

Correlation of nutritional status and pharmacokinetic variables

	INH				PZA
	C_max (µg/mL) Mean (95% CI)	P value	AUC₀₋₈ (µg/mL hour) Mean (95% CI)	P value	C_max (µg/mL) Mean (95% CI)	P value	AUC₀₋₈ (µg/mL hour) Mean (95% CI)	P value
Normal	2.9 (2.1 to 3.8)	0.6	13.8 (8.4 to 19.3)	0.60	35.7 (30.6 to 40.8)	0.2	188.3 (172.2 to 204.4)	0.1
Underweight (WAZ<2)	3.1 (2.1 to 4.1)	0.6	14.6 (9.1 to 20.2)	0.60	32.5 (27.4 to 37.7)	0.2	171.4 (144.7 to 198.1)	0.1
Normal	3.1 (2.4 to 3.7)	0.6	13.9 (10.8 to 17.0)	0.7	36.8 (32.9 to 40.7)	0.1	201.8 (176.5 to 227.1)	0.04*
Stunted (HAZ<2)	3.2 (1.9 to 4.4)	0.6	16.1 (8.7 to 23.6)	0.7	31.9 (25.9 to 37.9)	0.1	170.3 (140.9 to 199.7)	0.04*
Normal	4.1 (1.4 to 6.7)	0.1	17.8 (7.8 to 27.6)	0.2	39.5 (25.8 to 53.2)	0.1	212.2 (167.5 to 256.9)	0.01*
Wasted (WHZ<2)	2.6 (1.7 to 3.5)	0.1	12.8 (6.3 to 19.2)	0.2	30.5 (25.5 to 35.6)	0.1	159.6 (132.4 to 186.6)	0.01*
Normal	3.1 (2.4 to 3.8)	0.5	14.7 (11.3 to 18.0)	0.5	37.6 (34.0 to 41.2)	0.04*	208.8 (184.1 to 233.5)	0.01*
Low BMI (BMI<2)	3.1 (2.0 to 4.1)	0.5	14.8 (8.5 to 21.1)	0.5	31.9 (26.10 to 37.70)	0.04*	167.64 (139.11 to 196.18)	0.01*

*P value significant.
AUC₀₋₈, area under the time−concentration curve; BMI, body mass index; C_max, maximum peak concentration; HAZ, height for age; INH, isoniazid; PZA, pyrazinamide; WAZ, weight for age; WHZ, weight for height.