Factors influencing
| Factors | INH | PZA | ||||
| β | (95% CI) | P value | β | (95% CI) | P value | |
| A)Factors influencing peak drug concentrations (Cmax) | ||||||
| Univariate analysis | ||||||
| Age (years)† | 0.01 | (−0.2 to 0.2) | 0.9 | 0.9 | (0.1 to 1.7) | 0.03* |
| BMI | −0.01 | (−1.2 to 1.2) | 1.0 | −7.7 | (−13.8 to −1.6) | 0.02* |
| Type of TB‡ | 1.05 | (−0.1 to 2.2) | 0.1 | −1.6 | (−8.2 to 5.0) | 0.6 |
| Multivariate analysis | ||||||
| Age | NS | NS | ||||
| BMI | NS | −7.7 | (−13.8 to −1.6) | 0.02* | ||
| Type of TB | 1.05 | (−0.1 to 2.2) | 0.1 | NS | ||
| B)Factors influencing drug exposure (AUC0−8) | ||||||
| Univariate analysis | ||||||
| Age (years)† | −0.10 | (−0.9 to 0.7) | 0.8 | 6.5 | (2.0 to 11.0) | 0.01* |
| BMI | 0.8 | (−5.8 to 7.3) | 0.8 | −47.0 | (−82.4 to −11.6) | 0.01* |
| Type of TB‡ | 6.1 | (−0.1 to 12.3) | 0.05* | −12.9 | (−51.4 to 25.6) | 0.5 |
| Multivariate analysis | ||||||
| Age | NS | 8.4 | (3.6 to 13.1) | 0.001* | ||
| Type of TB | 6.1 | (−0.1 to 12.3) | 0.05* | NS | ||
*P value significant
†Age<3 years compared with >3 years.
‡Pulmonary TB compared with extrapulmonary TB.
BMI, body mass index; INH, i soniazid; NS, not significant; PZA, pyrazinamide; TB, tuberculosis. β, regression coefficient indicates change per 1 unit; stepwise linear regression was used.