Clinical and biochemical features at diagnosis of 66 patients with thyrotoxicosis in the west of Scotland seen between 1989 and 2012 with a diagnosis of Graves’ disease or Hashimoto’s thyroiditis
| Graves’ disease | Hashimoto’s thyroiditis | P value | |
| Number (F:M) | 53 F:45/M:8 | 13 F:13/M:0 | |
| Mean/median (range) age at time of diagnosis | 9.9/10.3 (1.8–15.8) | 12.3/13.4 (6–15.6) | 0.02 |
| Dose titration/block and replace | 34/19 | 12/1 | |
| TRAB+ve, eye signs +ve TRAB+ve, eye signs –ve TRAB+ve, eye signs N/A TRAB –ve/N/A, eye signs+ve | n=24 n=16 n=4 n=4/5 | Not applicable | |
| Eye signs | None (n=6) Lid lag/mild prominence (n=10) Definite exophthalmos (n=25) Marked exophthalmos (n=6) N/A (6) | Not applicable | |
| Goitre | None (5) Small (n=17) Moderate (n=20) Large (n=4) Not specified (n=7) | None (n=3) Small (n=4) Moderate (n=2) Large (n=0) Not specified (n=4) | 0.18 |
| First-degree relative with thyroid disease, for example, mother Second-degree relative affected, for example, aunt (n=30) | First degree (n=7) Second degree (n=15) First+second degree (n=3) | First degree (n=2) Second degree (n=2) First+second degree (n=1) | |
| Median (range) fT4 (pmol/L) (n=55) (reference range 10–23) | 62 (6.2–154.0) (n=42) | 40.4 (4.8–78.4) (n=13) | 0.01 |
| Median (range) TT4 (nmol/L) (n=55) (reference range 80–160) | 324 (45–1117) (n=42) | 293 (35–569) (n=13) | 0.09 |
| Median (range) TT3 (nmol/L) (n=48) (reference range 1.6–3.0) | 8.9 (2.2–22.9) (n=36) | 4.8 (3.1–8.9) (n=12) | 0.30 |
| Median (range) TRAB (U/L) (n=37) (reference range<10) | 36 (<3–94) (n=26) | <3 (<3–9) (n=13) | |
| Median (range) TRAB (%) (n=15) (reference range<10% displacement of TSH binding) | 46 (20–68) (n=15) | N/A | |
| Median (range) TPO (mU/L) (n=43) (reference range<30) | 419 (7–7643) (n=30) | 153 (10 to >2000) (n=13) | |
| Median (range) antimicrosomal titre (n=15) (reference range<1/400) | 1/1600 (<1/400–1/256 000) (n=15) | N/A (n=0) |
Where the data for a given row are fewer than the total patient number (66), the available number is given as (n=) in the left-hand column.
F, female; fT3, free tri-iodothyronine; fT4, free thyroxine; M, male; N/A, not available; N/K, not known; TPO, thyroid peroxidase; TRAB, TSH receptor antibody; TT3, total T3; TT4, total T4.