Baseline characteristics of the 90 children randomised
Characteristic | Hyoscine | Glycopyrronium | Total |
n=49 | n=41 | n=90 | |
Sex | |||
Female | 16 (33%) | 19 (46%) | 35 (39%) |
Male | 33 (67%) | 22 (54%) | 55 (61%) |
Age at randomisation | |||
Median (years) | 4.9 | 4.6 | 4.9 |
Range | (3.0, 14.5) | (3.0, 11.9) | (3.0, 14.5) |
Weight | |||
Median (kg) | 18.1 | 16.6 | 18.1 |
Range | (11.1, 79.4) | (10.4, 41.8) | (10.4, 79.4) |
Children with cerebral palsy | 10 (20%) | 12 (29%) | 22 (24%) |
Severity of drooling* | |||
Saliva usually on clothes | 43 (88%) | 35 (85%) | 78 (87%) |
Saliva usually on face | 6 (12%) | 6 (15%) | 12 (13%) |
Baseline Drooling Impact Scale | |||
n | 47 | 39 | 86 |
Mean (SD) | 57.9 (15.5) | 52.1 (12.7) | 55.3 (14.5) |
Median (Range) | 58 (26, 85) | 53 (25, 75) | 54.5 (25, 85) |
Baseline Drooling Severity and Frequency Scale† | |||
n | 35 | 33 | 68 |
Mean (SD) | 7.6 (1.1) | 7.6 (1.1) | 7.6 (1.1) |
Median (Range) | 8 (5, 9) | (5, 9) | 8 (5, 9) |
*Stratification factor at randomisation.
†Baseline scores for those whose treatment was tolerated to week-4.