Secondary outcomes
| SMC group | SMC+LP group | Crude difference in means (95% CI), P value | Adjusted difference in means* (95% CI), P value | n | Adjusted difference in means† (95% CI), P value | n | |||
| Mean | n | Mean | n | ||||||
| Chalder Fatigue score 6 months‡ | 19.8 | 37 | 14.4 | 44 | −5.4 (−8.6 to −2.1), 0.001 | −4.7 (−7.9 to −1.6), 0.003 | 80 | −5.4 (−8.9 to −1.9), 0.003 | 76 |
| Chalder Fatigue score 12 months‡ | 15.7 | 38 | 12.3 | 42 | −3.4 (−6.6 to −0.1), 0.04 | −3.2 (−6.3 to −0.1), 0.05 | 79 | −4.0 (−7.2 to −0.7), 0.02 | 74 |
| Pain VAS 6 months‡ | 32.8 | 28 | 23.4 | 33 | −9.5 (−23.5 to 4.6), 0.2 | −11.3 (−23.0 to 0.3), 0.06 | 58 | −9.3 (−21.1 to 2.6), 0.1 | 58 |
| Pain VAS 12 months‡ | 32.0 | 27 | 21.8 | 32 | −10.2 (−24.6 to 4.2), 0.2 | −9.4 (−21.5 to 2.7), 0.1 | 56 | −6.5 (−19.4 to 6.5), 0.3 | 54 |
| SCAS 6 months‡ | 37.4 | 28 | 24.7 | 33 | −12.7 (−22.0 to −3.3), 0.009 | −8.7 (−16.9 to −0.5), 0.04 | 61 | −10.0 (−18.5 to −1.5), 0.02 | 58 |
| SCAS 12 months‡ | 36.3 | 27 | 19.6 | 31 | −16.7 (−25.9 to −7.5), 0.001 | −12.1 (−20.1 to −4.1), 0.004 | 56 | −14.5 (−22.4 to −6.7), <0.001 | 52 |
| HADS anxiety score 6 months‡ | 9.7 | 28 | 6.1 | 33 | −3.7 (−6.0 to −1.3), 0.003 | −3.3 (−5.6 to −1.0), 0.005 | 60 | −3.5 (−5.6 to −1.5), 0.001 | 57 |
| HADS anxiety score 12 months‡ | 8.3 | 27 | 5.3 | 33 | −3.1 (−5.2 to −0.9), 0.006 | −2.8 (−4.7 to −0.8), 0.006 | 59 | −2.6 (−4.7 to −0.4), 0.019 | 53 |
| HADS depression score 6 months‡ | 5.9 | 28 | 4.2 | 33 | −1.7 (−4.0 to 0.6), 0.1 | −1.6 (−3.9 to 0.7), 0.2 | 59 | −1.5 (−3.5 to 0.5), 0.1 | 57 |
| HADS depression score 12 months‡ | 4.6 | 27 | 2.8 | 33 | −1.9 (−3.6 to −0.2), 0.03 | −1.7 (−3.3 to −0.2), 0.03 | 58 | −1.8 (−3.4 to −0.1), 0.04 | 53 |
| School/college attendance in the previous week 6 months§ (days) | 2.6 | 37 | 3.2 | 41 | 0.7 (−0.1 to 1.4), 0.08 | 0.7 (0.0 to 1.4), 0.06 | 77 | 0.6 (−0.2 to 1.4), 0.1 | 72 |
| School/college attendance in the previous week 12 months§ (days) | 3.1 | 36 | 4.1 | 34 | 1.0 (0.2 to 1.7), 0.01 | 0.9 (0.2 to 1.6), 0.02 | 69 | 1.0 (0.2 to 1.8), 0.01 | 65 |
*Adjusted for age, gender and baseline outcome.
†Adjusted for age, gender, baseline outcome, baseline SCAS and VAS (as appropriate).
‡Higher score=more symptoms, poorer function.
§Higher score=fewer symptoms, better function.
HADS, Hospital Anxiety and Depression Scale; LP, Lightning Process; SCAS, Spence Children’s Anxiety Scale; SF-36, 36-item Short-Form health survey; SMC, specialist medical care; VAS, visual analogue scale.