What dose of aspirin should be used in the initial treatment of Kawasaki disease?
| Guideline | Recommended aspirin treatment (with 2 kg/day intravenous immunoglobulin single infusion) | Recommended duration of aspirin | Additional comments |
| American Heart Association19 (USA, 2017) | Moderate-dose (30–50 mg/kg/day) or high-dose (80–100 mg/kg/day) | Until afebrile, then low-dose (3–5 mg/kg/day) for 6–8 weeks | Recommends continuing low-dose aspirin for patients with coronary abnormalities |
| Eleftheriou et al, Archives of Disease in Childhood
20 (UK, 2014) | Moderate-dose (30–50 mg/kg/day) | Until afebrile and inflammation subsided, then low-dose (3–5 mg/kg/day) for 6–8 weeks | Recommends continuing low-dose aspirin for patients with coronary abnormalities ‘until aneurysms resolve’ |
| Japanese Circulation Society21 (Japan, 2014) | Low-dose (3–5 mg/kg/day) Consider other antiplatelet drugs (dipyridamole 2–5 mg/kg/day or ticlopidine 5–7 mg/kg/day) | ‘About 3 months’ | Recommends continuing low-dose aspirin for patients with coronary abnormalities |
| The Royal Children’s Hospital Melbourne22 (Australia, 2007) | Low-dose (3–5 mg/kg/day) | 6–8 weeks |