Table 2

Treatment regimens of trials included for meta-analysis, comparing conservative treatment versus appendicectomy in children with uncomplicated appendicitis

First authorRefDietIntravenous antibioticsDuration of intravenous antibiotics* (days)Oral antibioticsDuration of oral treatment† (days)
Hartwich13No dietPiperacillin-tazobactam0.3 (2 doses, 8 hours)Amoxicillin-clavulanic acid7
Minneci14Nothing by mouth for at least 12 hoursPiperacillin-tazobactam; or ciprofloxacin, metronidazoleOne or moreAmoxicillin-clavulanic acid; or ciprofloxacin, metronidazole9
Mudri15NRCiprofloxacin, metronidazole1 (median 24 hours)Amoxicillin-clavulanic acid7
Svensson16Nothing per os for 24 hours, with protocol violations (n NR)Meropenem, metronidazoleTwo or moreCiprofloxacin, metronidazole8
Tanaka17No dietCefmetazole for 2 days; if no decrease of white blood cell count over 25%:
ampicillin-sulbactam, ceftazidime or meropenem or imipenem-cilastatin, gentamicin
6.6 (mean)No oral treatment
  • *Decision for cessation of intravenous antibiotics was based on clinical improvement or the absence of deterioration in four studies12 14 16 and not reported in one study.15 In one study antibiotics were only administered intravenously with the condition that a level of C reactive protein of less than 0.5 mg/dL was required before cessation.17

  • †Decision for cessation of oral antibiotics was based on the predefined study schedule in the four studies using oral antibiotics.13–16

  • NR, not reported; Ref, Reference number as in reference list.