Characteristics of children with and without inherited bleeding disorders
| Non-bleeding disorder | Severe bleeding disorder | Mild/ moderate bleeding disorder | ||
|---|---|---|---|---|
| Subjects | 328 | 57 | 46 | |
| Age at enrolment in years Mean (SD) | 1.58 (1.45) | 2.66 (1.66) | 2.43 (1.78) | |
| Gender (M/F) | 145 (46%)/168 (54%) | 56 (98%)/1(2%) | 31 (69%)/14 (31%) | |
| Missing data | 15 | 0 | 1 | |
| Diagnosis | No prophylaxis | Prophylaxis | ||
| Haemophilia* | 27 (47%) | 24 (42%) | 23 (50%) | |
| VWD | NA | 6 (11%) | 0 (0%) | 23 (50%) |
| Collections† | No prophylaxis | Prophylaxis | ||
| Pre mobile | 1010 (39%) | 64 (18%) | 0 (0%) | 59 (11%) |
| Early mobile | 478 (19%) | 64 (18%) | 12 (5%) | 70 (13%) |
| Walking | 1082 (42%) | 229 (64%) | 255 (95%) | 393 (75%) |
| Total | 2570 | 357 | 267 | 522 |
The children with a bleeding disorder (BD) had mean (range) 11 (1–36) collections/child. At the first collection for the bleeding disorder group, 15 children were premobile, 10 early mobile and 78 walking. At first collection for the non-bleeding disorder group 133 children were premobile, 43 early mobile and 152 walking.
*The haemophilia group included 61 with haemophilia A, 10 with haemophilia B, 3 with factor XI deficiency. All children with factor XI deficiency were in the non-severe group.
†Some subjects contributed collections in more than one developmental stage; of the 431 children (excluding the 2 with platelet disorders) 356 remained in a single developmental stage, 65 crossed two and 10 crossed three stages. Some children moved from on demand to prophylaxis. The two patients with platelet function disorders have not been included.
NA, not applicable; VWD, von Willebrand disease.